STX2 and STXBP2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		STX2	STXBP2
Description		syntaxin 2	syntaxin binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Protein-containing Complex Intracellular Membrane-bounded Organelle Presynaptic Active Zone Membrane	Extracellular Region Cytosol Plasma Membrane Apical Plasma Membrane Secretory Granule Specific Granule Azurophil Granule Zymogen Granule Membrane Cytolytic Granule Phagocytic Vesicle Extracellular Exosome Tertiary Granule Presynapse
	Molecular Function	SNARE Binding Structural Molecule Activity SNAP Receptor Activity Protein Binding Identical Protein Binding Calcium-dependent Protein Binding	Protein Binding Syntaxin-1 Binding Syntaxin Binding Syntaxin-3 Binding
	Biological Process	Intracellular Protein Transport Exocytosis Signal Transduction Acrosome Reaction Ectoderm Development Animal Organ Morphogenesis Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress Vesicle Docking Cornified Envelope Assembly	Leukocyte Mediated Cytotoxicity Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Regulation Of Mast Cell Degranulation Neutrophil Degranulation Regulated Exocytosis Cellular Response To Type II Interferon Presynaptic Dense Core Vesicle Exocytosis
Pathways			Platelet degranulation Other interleukin signaling
Drugs
Diseases
GWAS		Initial pursuit acceleration in psychotic disorders ( 29064472) Metabolite levels ( 23823483) Plasma plasminogen activator levels ( 24578379) vWF levels ( 30586737)
Interacting Genes		65 interacting genes: AARD ABI3 ANKRD46 APOL2 BET1 BLOC1S2 CD53 CDC23 CERT1 CPLX2 CTSA CYBC1 EBAG9 ENTPD3 FGA GET1 GIMAP5 MIP MRPL11 MTG1 NAPB NINJ2 PCGF2 PLN PLPP4 RMDN3 RNF4 RTP2 SEC22A SEC22B SERP1 SLC18A1 SNAP25 SNAP29 SNCA STRIT1 STX12 STX16 STX1A STX1B STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5L SYT1 SYT4 SYT7 TMEM120A TMEM120B TSPAN8 UBE2I UNC13B VAMP2 VAMP3 VAMP5 VAPB VTI1B ZCCHC12 ZFPL1 ZNF785	14 interacting genes: DDX20 FILNC1 GEMIN2 GEMIN4 SMN1 SNAP23 SNRPB SNRPD2 SNRPD3 STX1A STX2 STX3 STXBP3 VAMP2
Entrez ID		2054	6813
HPRD ID		11816	03423
Ensembl ID		ENSG00000111450	ENSG00000076944
Uniprot IDs		A0A994J5V9 A0A994J840 P32856	Q15833 Q53GF4
PDB IDs			4CCA
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Organelle Localization By Membrane Tethering SNARE Binding Membrane Docking Vesicle Docking Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Organization Membrane Organization Organelle Localization Syntaxin Binding Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Exocytosis Exocytosis Calcium-ion Regulated Exocytosis Cellular Localization Syntaxin-1 Binding Secretion By Cell Regulated Exocytosis Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport In Synapse Neurotransmitter Transport Calcium Ion-regulated Exocytosis Of Neurotransmitter Establishment Of Protein Localization Intracellular Transport Protein Transport Secretion Endomembrane System Signal Release SNARE Complex Assembly Synaptic Vesicle Membrane Membrane Regulation Of Exocytosis Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Priming Regulation Of Secretion Positive Regulation Of Exocytosis Intracellular Protein Transport Vesicle Intracellular Protein Localization Synaptic Vesicle Neuronal Dense Core Vesicle Exocytosis Regulation Of Vesicle Fusion Positive Regulation Of Synaptic Transmission Synaptic Vesicle Priming Positive Regulation Of Calcium Ion-dependent Exocytosis	SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SNAP Receptor Activity SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies SNARE Complex Spliceosomal Complex Assembly Small Nuclear Ribonucleoprotein Complex Protein-containing Complex Assembly RNA Splicing Exocytosis Vesicle Fusion Cellular Component Assembly Organelle Membrane Fusion Protein-containing Complex Organization 7-methylguanosine Cap Hypermethylation MRNA Processing Organelle Fusion U4 SnRNP Methylosome Vesicle Organization Membrane Fusion Vesicle Docking Specific Granule SNARE Binding MRNA Metabolic Process Organelle Localization By Membrane Tethering U1 SnRNP Secretion By Cell U5 SnRNP RNA Splicing, Via Transesterification Reactions Membrane Docking Vesicle-mediated Transport In Synapse U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Secretory Granule U2-type Spliceosomal Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex U2-type Catalytic Step 2 Spliceosome Secretion Synaptic Vesicle Exocytosis RNA Processing Calcium-ion Regulated Exocytosis Histone Pre-mRNA DCP Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex U4/U6 X U5 Tri-snRNP Complex Neuron Projection
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