STXBP1 and STX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STXBP1	STX5
Description		syntaxin binding protein 1	syntaxin 5
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Parallel Fiber To Purkinje Cell Synapse Presynapse Postsynapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Glutamatergic Synapse Presynaptic Cytosol	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bounding Membrane Of Organelle
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding	SNARE Binding SNAP Receptor Activity Protein Binding Cadherin Binding
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Neuron Apoptotic Process Establishment Of Localization In Cell Long-term Synaptic Depression Platelet Aggregation Cellular Response To Type II Interferon Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Regulated Secretory Pathway Regulation Of Acrosomal Vesicle Exocytosis	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle Fusion Vesicle-mediated Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Vesicle Docking Golgi Disassembly Regulation Of Golgi Organization
Pathways		Regulation of insulin secretion Neurexins and neuroligins	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle RHOC GTPase cycle RHOG GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		35 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG RIPPLY3 SPICE1 SPTBN1 SQSTM1 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 TTC3 USO1	48 interacting genes: AARD APLP1 AQP6 BAG6 BET1 COPS6 CRB3 CREB3L3 DRC12 EBP FAM209A GOSR1 GOSR2 GPANK1 GPR152 HAP1 HSD17B13 IMMT JAGN1 KASH5 LMNA LNX1 LRIF1 LRRC4C MAGEA6 MTUS1 NAPA NAPB NSFL1C REEP4 RETREG3 SCFD1 SEC22B SNAP23 SNAP25 STING1 STX1A STX2 STX3 STX4 STXBP1 TACC1 TMEM31 TP53 USO1 VAPB VCP VCPIP1
Entrez ID		6812	6811
HPRD ID		04235	04426
Ensembl ID		ENSG00000136854	ENSG00000162236
Uniprot IDs		A0A0D9SG72 A0A1B0GTP9 A0A1B0GVQ5 A0A1B0GWF2 P61764	B4DKR0 Q13190
PDB IDs		6L03	3EFO
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Regulation Of Exocytosis Vesicle-mediated Transport Positive Regulation Of Exocytosis SNARE Complex Vesicle Docking Intracellular Protein Transport Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Secretion By Cell Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Transport Positive Regulation Of Secretion SNAP Receptor Activity Organelle Localization By Membrane Tethering Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization Establishment Of Localization In Cell Organelle Localization Membrane Docking Regulation Of Transport Vesicle-mediated Transport In Synapse Positive Regulation Of Calcium Ion-dependent Exocytosis Membrane Organization Vesicle Fusion Organelle Membrane Fusion Neurofibrillary Tangle Secretion By Cell Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Spontaneous Neurotransmitter Secretion Regulation Of Secretion By Cell Regulation Of Synaptic Plasticity Chemical Synaptic Transmission Positive Regulation Of Protein Localization Regulation Of Regulated Secretory Pathway Vesicle Organization SNARE Binding Positive Regulation Of Establishment Of Protein Localization Organelle Fusion Presynaptic Active Zone Membrane Trans-synaptic Signaling Intracellular Transport Neuron Projection Regulation Of Secretion Presynapse Synaptic Signaling Regulation Of Signaling Regulation Of Cell Communication	SNAP Receptor Activity Membrane Fusion Membrane Organization SNARE Complex Organelle Membrane Fusion Organelle Fusion Vesicle Fusion Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization SNARE Binding Vesicle-mediated Transport Intracellular Transport Cellular Localization Vesicle Organization Organelle Localization By Membrane Tethering Membrane Docking Organelle Localization Vesicle Docking Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Protein Transport Intracellular Protein Localization Golgi Vesicle Transport Exocytosis Regulation Of Synaptic Vesicle Priming Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptic Vesicle Priming Syntaxin Binding Endoplasmic Reticulum Endoplasmic Reticulum Organization Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Specific Granule VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Neurotransmitter Transport Synaptic Vesicle Membrane Organization Secretion Membrane Membrane Assembly Secretory Granule Localization Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Endoplasmic Reticulum Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
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