STXBP1 and NEFM

Number of citations of the paper that reports this interaction (PubMedID 12963086)
0

Data Source:
HPRD (in vivo)

		STXBP1	NEFM
Description		syntaxin binding protein 1	neurofilament medium chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Parallel Fiber To Purkinje Cell Synapse Presynapse Postsynapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Glutamatergic Synapse Presynaptic Cytosol	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Axon Cell Projection Intermediate Filament Cytoskeleton Neurofibrillary Tangle Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Neuron Apoptotic Process Establishment Of Localization In Cell Long-term Synaptic Depression Platelet Aggregation Cellular Response To Type II Interferon Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Regulated Secretory Pathway Regulation Of Acrosomal Vesicle Exocytosis	Neurofilament Bundle Assembly
Pathways		Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)	Brain morphology (MOSTest) ( 32665545) Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)
Interacting Genes		35 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG RIPPLY3 SPICE1 SPTBN1 SQSTM1 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 TTC3 USO1	12 interacting genes: APOE DISC1 DRD2 DSCAM FOS ITSN1 MINK1 NEFH RB1 SMAD2 STXBP1 TNIK
Entrez ID		6812	4741
HPRD ID		04235	01205
Ensembl ID		ENSG00000136854	ENSG00000104722
Uniprot IDs		A0A0D9SG72 A0A1B0GTP9 A0A1B0GVQ5 A0A1B0GWF2 P61764	P07197 Q9UK51
PDB IDs		6L03
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Regulation Of Exocytosis Vesicle-mediated Transport Positive Regulation Of Exocytosis SNARE Complex Vesicle Docking Intracellular Protein Transport Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Secretion By Cell Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Transport Positive Regulation Of Secretion SNAP Receptor Activity Organelle Localization By Membrane Tethering Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization Establishment Of Localization In Cell Organelle Localization Membrane Docking Regulation Of Transport Vesicle-mediated Transport In Synapse Positive Regulation Of Calcium Ion-dependent Exocytosis Membrane Organization Vesicle Fusion Organelle Membrane Fusion Neurofibrillary Tangle Secretion By Cell Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Spontaneous Neurotransmitter Secretion Regulation Of Secretion By Cell Regulation Of Synaptic Plasticity Chemical Synaptic Transmission Positive Regulation Of Protein Localization Regulation Of Regulated Secretory Pathway Vesicle Organization SNARE Binding Positive Regulation Of Establishment Of Protein Localization Organelle Fusion Presynaptic Active Zone Membrane Trans-synaptic Signaling Intracellular Transport Neuron Projection Regulation Of Secretion Presynapse Synaptic Signaling Regulation Of Signaling Regulation Of Cell Communication	Cell Projection Organization Axon Intracellular Signal Transduction Intracellular Signaling Cassette Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Glutamatergic Synapse Cell Projection Morphogenesis Neuron Projection Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Cellular Component Organization Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Dendritic Spine Development Positive Regulation Of Cell Development Modulation Of Chemical Synaptic Transmission Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Growth Hormone Secretion Regulation Of Axon Extension Cell-cell Signaling Regulation Of Growth Signal Transduction Regulation Of Growth Hormone Secretion Regulation Of Synapse Organization Positive Regulation Of Multicellular Organismal Process Signaling Regulation Of Developmental Growth Regulation Of Cellular Component Organization Cell Communication Intracellular Protein Localization Identical Protein Binding Memory Protein-containing Complex Binding Positive Regulation Of Cell Projection Organization Cell Population Proliferation Regulation Of Neurogenesis Regulation Of Postsynapse Organization Regulation Of Cell Growth Negative Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of Cell Development
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