STXBP1 and CENPP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STXBP1	CENPP
Description		syntaxin binding protein 1	centromere protein P
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Parallel Fiber To Purkinje Cell Synapse Presynapse Postsynapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Glutamatergic Synapse Presynaptic Cytosol	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding	Protein Binding
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Neuron Apoptotic Process Establishment Of Localization In Cell Long-term Synaptic Depression Platelet Aggregation Cellular Response To Type II Interferon Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Regulated Secretory Pathway Regulation Of Acrosomal Vesicle Exocytosis	Chromosome Segregation CENP-A Containing Chromatin Assembly
Pathways		Regulation of insulin secretion Neurexins and neuroligins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)	End-stage renal disease ( 29885931) HDL cholesterol levels ( 32203549) Height ( 28552196 31562340) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		35 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG RIPPLY3 SPICE1 SPTBN1 SQSTM1 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 TTC3 USO1	26 interacting genes: AKAP19 ATP6V0D2 BACH2 CCDC33 CCDC85B CEP44 GOLGA2 HAUS1 KIAA1328 KLC3 LMNA MBD3 NHLH1 NTAQ1 PKNOX2 POLR3K RNF126 RPIA SERTAD3 STXBP1 SYCE1L TEX11 TOX2 USHBP1 ZNF341 ZNF765
Entrez ID		6812	401541
HPRD ID		04235	17989
Ensembl ID		ENSG00000136854	ENSG00000188312
Uniprot IDs		A0A0D9SG72 A0A1B0GTP9 A0A1B0GVQ5 A0A1B0GWF2 P61764	Q6IPU0
PDB IDs		6L03	7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Regulation Of Exocytosis Vesicle-mediated Transport Positive Regulation Of Exocytosis SNARE Complex Vesicle Docking Intracellular Protein Transport Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Secretion By Cell Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Transport Positive Regulation Of Secretion SNAP Receptor Activity Organelle Localization By Membrane Tethering Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization Establishment Of Localization In Cell Organelle Localization Membrane Docking Regulation Of Transport Vesicle-mediated Transport In Synapse Positive Regulation Of Calcium Ion-dependent Exocytosis Membrane Organization Vesicle Fusion Organelle Membrane Fusion Neurofibrillary Tangle Secretion By Cell Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Spontaneous Neurotransmitter Secretion Regulation Of Secretion By Cell Regulation Of Synaptic Plasticity Chemical Synaptic Transmission Positive Regulation Of Protein Localization Regulation Of Regulated Secretory Pathway Vesicle Organization SNARE Binding Positive Regulation Of Establishment Of Protein Localization Organelle Fusion Presynaptic Active Zone Membrane Trans-synaptic Signaling Intracellular Transport Neuron Projection Regulation Of Secretion Presynapse Synaptic Signaling Regulation Of Signaling Regulation Of Cell Communication	Centrosome Cycle
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