STXBP1 and NEFH

Number of citations of the paper that reports this interaction (PubMedID 12963086)
0

Data Source:
HPRD (in vivo)

		STXBP1	NEFH
Description		syntaxin binding protein 1	neurofilament heavy chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Parallel Fiber To Purkinje Cell Synapse Presynapse Postsynapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Glutamatergic Synapse Presynaptic Cytosol	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Postsynaptic Density Axon Cell Projection Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Neuron Apoptotic Process Establishment Of Localization In Cell Long-term Synaptic Depression Platelet Aggregation Cellular Response To Type II Interferon Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Regulated Secretory Pathway Regulation Of Acrosomal Vesicle Exocytosis	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Intermediate Filament Cytoskeleton Organization Intermediate Filament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor
Pathways		Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)
Interacting Genes		35 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG RIPPLY3 SPICE1 SPTBN1 SQSTM1 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 TTC3 USO1	6 interacting genes: ERBB2 MAPK1 NEFL NEFM PKN1 STXBP1
Entrez ID		6812	4744
HPRD ID		04235	01204
Ensembl ID		ENSG00000136854	ENSG00000100285
Uniprot IDs		A0A0D9SG72 A0A1B0GTP9 A0A1B0GVQ5 A0A1B0GWF2 P61764	P12036
PDB IDs		6L03
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Regulation Of Exocytosis Vesicle-mediated Transport Positive Regulation Of Exocytosis SNARE Complex Vesicle Docking Intracellular Protein Transport Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Secretion By Cell Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Transport Positive Regulation Of Secretion SNAP Receptor Activity Organelle Localization By Membrane Tethering Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization Establishment Of Localization In Cell Organelle Localization Membrane Docking Regulation Of Transport Vesicle-mediated Transport In Synapse Positive Regulation Of Calcium Ion-dependent Exocytosis Membrane Organization Vesicle Fusion Organelle Membrane Fusion Neurofibrillary Tangle Secretion By Cell Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Spontaneous Neurotransmitter Secretion Regulation Of Secretion By Cell Regulation Of Synaptic Plasticity Chemical Synaptic Transmission Positive Regulation Of Protein Localization Regulation Of Regulated Secretory Pathway Vesicle Organization SNARE Binding Positive Regulation Of Establishment Of Protein Localization Organelle Fusion Presynaptic Active Zone Membrane Trans-synaptic Signaling Intracellular Transport Neuron Projection Regulation Of Secretion Presynapse Synaptic Signaling Regulation Of Signaling Regulation Of Cell Communication	Neurofilament Bundle Assembly Postsynaptic Intermediate Filament Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Intermediate Filament Bundle Assembly Neurofilament Schwann Cell Development Phospholipase Binding ERBB2 Signaling Pathway Regulation Of Leukocyte Proliferation Intermediate Filament Cytoskeleton Cell Death Apoptotic Process Programmed Cell Death Response To Epidermal Growth Factor Protein Phosphorylation Phosphorylation Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Axon Intermediate Filament Organization Negative Regulation Of Lymphocyte Proliferation ERBB Signaling Pathway Protein Kinase Activity Negative Regulation Of Mononuclear Cell Proliferation Neuromuscular Junction Myelination Axon Ensheathment Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Modulation Of Chemical Synaptic Transmission Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Vesicle Docking Negative Regulation Of Leukocyte Proliferation Structural Constituent Of Cytoskeleton Glial Cell Differentiation ERBB3:ERBB2 Complex Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Neuron Apoptotic Process Presynaptic Intermediate Filament Cytoskeleton Cytosine Metabolic Process Kinase Activity RNA Polymerase I Core Binding Regulation Of Immune System Process Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Histone H3T11 Kinase Activity Positive Regulation Of Synaptic Transmission Interleukin-34-mediated Signaling Pathway
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