STXBP1 and SPICE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STXBP1	SPICE1
Description		syntaxin binding protein 1	spindle and centriole associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Parallel Fiber To Purkinje Cell Synapse Presynapse Postsynapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Glutamatergic Synapse Presynaptic Cytosol	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Plasma Membrane Ciliary Basal Body
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding	Protein Binding
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Neuron Apoptotic Process Establishment Of Localization In Cell Long-term Synaptic Depression Platelet Aggregation Cellular Response To Type II Interferon Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Regulated Secretory Pathway Regulation Of Acrosomal Vesicle Exocytosis	Regulation Of Centriole Replication Cell Division Metaphase Chromosome Alignment Mitotic Spindle Assembly
Pathways		Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)	Prostate cancer ( 23535732)
Interacting Genes		35 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG RIPPLY3 SPICE1 SPTBN1 SQSTM1 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 TTC3 USO1	2 interacting genes: KDM1A STXBP1
Entrez ID		6812	152185
HPRD ID		04235	11242
Ensembl ID		ENSG00000136854	ENSG00000163611
Uniprot IDs		A0A0D9SG72 A0A1B0GTP9 A0A1B0GVQ5 A0A1B0GWF2 P61764	Q8N0Z3
PDB IDs		6L03
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Regulation Of Exocytosis Vesicle-mediated Transport Positive Regulation Of Exocytosis SNARE Complex Vesicle Docking Intracellular Protein Transport Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Secretion By Cell Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Transport Positive Regulation Of Secretion SNAP Receptor Activity Organelle Localization By Membrane Tethering Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization Establishment Of Localization In Cell Organelle Localization Membrane Docking Regulation Of Transport Vesicle-mediated Transport In Synapse Positive Regulation Of Calcium Ion-dependent Exocytosis Membrane Organization Vesicle Fusion Organelle Membrane Fusion Neurofibrillary Tangle Secretion By Cell Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Spontaneous Neurotransmitter Secretion Regulation Of Secretion By Cell Regulation Of Synaptic Plasticity Chemical Synaptic Transmission Positive Regulation Of Protein Localization Regulation Of Regulated Secretory Pathway Vesicle Organization SNARE Binding Positive Regulation Of Establishment Of Protein Localization Organelle Fusion Presynaptic Active Zone Membrane Trans-synaptic Signaling Intracellular Transport Neuron Projection Regulation Of Secretion Presynapse Synaptic Signaling Regulation Of Signaling Regulation Of Cell Communication	Axon Target Recognition Developmental Maturation Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of Acrosomal Vesicle Exocytosis Protein Demethylase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Platelet Degranulation Regulation Of Glutamate Secretion, Neurotransmission MRF Binding Neuronal Dense Core Vesicle Exocytosis Response To Fungicide Guanine Metabolic Process Synaptic Vesicle Maturation Dense Core Granule Exocytosis Histone H3K4 Demethylase Activity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Cellular Component Organization Regulation Of SNARE Complex Assembly Secretory Granule Localization Platelet Alpha Granule Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Protein-containing Complex Regulation Of Glutamate Secretion Negative Regulation Of Apoptotic Process Parallel Fiber To Purkinje Cell Synapse Positive Regulation Of Glutamate Secretion Phospholipase Binding Positive Regulation Of Amino Acid Transport Long-term Synaptic Depression Positive Regulation Of Mast Cell Degranulation Presynaptic Active Zone Cytoplasmic Component Syntaxin-1 Binding Synaptic Vesicle Priming Histone H3K9 Demethylase Activity Purine Nucleobase Metabolic Process Positive Regulation Of Cell Size Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone Demethylase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
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