STX5 and GOSR2

Number of citations of the paper that reports this interaction (PubMedID 9647643)
53

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		STX5	GOSR2
Description		syntaxin 5	golgi SNAP receptor complex member 2
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bounding Membrane Of Organelle	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Cadherin Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle Fusion Vesicle-mediated Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Vesicle Docking Golgi Disassembly Regulation Of Golgi Organization	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle RHOC GTPase cycle RHOG GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Aortic root size ( 28394258) Aortic valve area ( 33125279) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Congenital heart disease (anomalies of thoracic arteries and veins) ( 33201861) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Pulse pressure ( 28739976 27841878 30578418) QRS duration ( 27577874 21076409 30012220) QT interval ( 29874175) Systolic blood pressure ( 30578418 27618447 28739976 27618452 28135244 21909115 27841878)
Interacting Genes		48 interacting genes: AARD APLP1 AQP6 BAG6 BET1 COPS6 CRB3 CREB3L3 DRC12 EBP FAM209A GOSR1 GOSR2 GPANK1 GPR152 HAP1 HSD17B13 IMMT JAGN1 KASH5 LMNA LNX1 LRIF1 LRRC4C MAGEA6 MTUS1 NAPA NAPB NSFL1C REEP4 RETREG3 SCFD1 SEC22B SNAP23 SNAP25 STING1 STX1A STX2 STX3 STX4 STXBP1 TACC1 TMEM31 TP53 USO1 VAPB VCP VCPIP1	53 interacting genes: APP AQP6 ARF1 ARL13B BIK BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 ERGIC3 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SLC35H1 SLC61A1 SLC71A2 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1
Entrez ID		6811	9570
HPRD ID		04426	04937
Ensembl ID		ENSG00000162236	ENSG00000108433
Uniprot IDs		B4DKR0 Q13190	A0A1W2PPP5 A0A1W2PQ77 A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRC2 A0A1W2PRL0 I3NI02 O14653
PDB IDs		3EFO	3EG9
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity Membrane Fusion Membrane Organization SNARE Complex Organelle Membrane Fusion Organelle Fusion Vesicle Fusion Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization SNARE Binding Vesicle-mediated Transport Intracellular Transport Cellular Localization Vesicle Organization Organelle Localization By Membrane Tethering Membrane Docking Organelle Localization Vesicle Docking Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Protein Transport Intracellular Protein Localization Golgi Vesicle Transport Exocytosis Regulation Of Synaptic Vesicle Priming Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptic Vesicle Priming Syntaxin Binding Endoplasmic Reticulum Endoplasmic Reticulum Organization Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Specific Granule VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Neurotransmitter Transport Synaptic Vesicle Membrane Organization Secretion Membrane Membrane Assembly Secretory Granule Localization Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Endoplasmic Reticulum Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ascorbate Homeostasis Positive Regulation Of Protein Localization To Cell Surface Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Vesicle Docking Bile Acid:sodium Symporter Activity Organelle Localization By Membrane Tethering Membrane Fusion Regulation Of Toll Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Membrane Docking SNAP Receptor Activity Protein Binding Fatty Acid Elongation, Saturated Fatty Acid Vesicle Fusion Regulation Of Protein Localization To Cell Surface Organelle Membrane Fusion Meiotic Nuclear Membrane Microtubule Tethering Complex SNARE Complex Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acetylcholine Receptor Binding Very Long-chain Fatty Acid Biosynthetic Process Organelle Fusion Fatty Acid Elongation Endoplasmic Reticulum Organization
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