STRN and LNX1

Number of citations of the paper that reports this interaction (PMID 22889411)
1

Data Source:
BioGRID (two hybrid)

		STRN	LNX1
Gene Name		striatin, calmodulin binding protein	ligand of numb-protein X 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Tight Junction Postsynaptic Density Membrane Neuronal Cell Body Dendritic Spine Postsynaptic Membrane	Cytoplasm
	Molecular Function	Protein Binding Calmodulin Binding Estrogen Receptor Binding Protein Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding
	Biological Process	Locomotory Behavior Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Dendrite Development Tight Junction Assembly	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)	DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		11 interactors: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11	218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593
Entrez ID		6801	84708
HPRD ID		18124	17287
Ensembl ID		ENSG00000115808	ENSG00000072201
Uniprot IDs		O43815	Q8TBB1
PDB IDs			3B76
Enriched GO Terms of Interacting Partners?		Negative Regulation Of JAK-STAT Cascade Regulation Of Protein Autophosphorylation Inactivation Of MAPK Activity Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Oxidoreductase Activity Negative Regulation Of MAP Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Mitotic Nuclear Envelope Reassembly Regulation Of JAK-STAT Cascade Negative Regulation Of Protein Phosphorylation Nuclear Envelope Reassembly Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Membrane Organization Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Second-messenger-mediated Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Monooxygenase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Nitric Oxide Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Reactive Nitrogen Species Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Protein Kinase Activity Regulation Of Signaling Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Kinase Activity Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Transmembrane Transport Negative Regulation Of Transferase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process
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