STRN and PDCD10

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		STRN	PDCD10
Name		striatin	programmed cell death 10
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Postsynaptic Density Membrane Cell Junction Dendrite Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane FAR/SIN/STRIPAK Complex Postsynapse	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding Calmodulin Binding Nuclear Estrogen Receptor Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Protein Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Locomotory Behavior Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Dendrite Development Bicellular Tight Junction Assembly	Angiogenesis Endothelium Development Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAP Kinase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Notch Signaling Pathway Regulation Of Angiogenesis Protein Stabilization Establishment Of Golgi Localization Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Reassembly Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Extra-nuclear estrogen signaling Signaling by cytosolic PDGFRA and PDGFRB fusion proteins ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	None
Diseases		None	Cerebral cavernous malformation
GWAS		Alanine aminotransferase levels ( 33547301 ) Alanine transaminase levels ( 29403010 ) Appendicular lean mass ( 33097823 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive decline (age-related) ( 28078323 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597 ) Immature fraction of reticulocytes ( 27863252 ) Mean platelet volume ( 32888494 ) Metabolite levels ( 23823483 ) PR interval ( 32439900 ) QRS duration ( 27659466 27577874 ) Red cell distribution width ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) TPE interval (resting) ( 32386560 ) Triglyceride levels ( 32203549 32154731 )	Fast beta electroencephalogram ( 28070124 ) Platelet count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: RHOA
Interacting Genes		12 interacting genes: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PDCD10 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11	9 interacting genes: CHMP5 FAM118B FARSA FRYL MINAR1 PLEKHS1 STK24 STK25 STRN
Entrez ID		6801	11235
HPRD ID		18124	10141
Ensembl ID		ENSG00000115808	ENSG00000114209
Uniprot IDs		O43815	Q9BUL8
PDB IDs		Not available	3AJM 3L8I 3L8J 3RQE 3RQF 3RQG 3W8H 3W8I 4GEH 4TVQ
GO Terms Enriched among Interactors		FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Communication By Electrical Coupling Intracellular Signal Transduction INTAC Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Hippo Signaling Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Kinase Binding T Cell Homeostasis Nuclear RNA Surveillance Membrane Raft Fibroblast Proliferation RNA Surveillance Sister Chromatid Cohesion Protein Phosphatase Regulator Activity Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Muscle System Process Regulation Of Signaling Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Endothelial Cell Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Regulation Of Action Potential Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Lymphocyte Homeostasis Regulation Of Nitric Oxide Metabolic Process Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Response To Metal Ion	FAR/SIN/STRIPAK Complex Regulation Of Neuron Projection Development Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Mitotic Cytokinetic Process Cytokinetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation