STRN and GNAI1

Number of citations of the paper that reports this interaction (PMID 15569929)
44

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		STRN	GNAI1
Gene Name		striatin, calmodulin binding protein	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Tight Junction Postsynaptic Density Membrane Neuronal Cell Body Dendritic Spine Postsynaptic Membrane	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Estrogen Receptor Binding Protein Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Locomotory Behavior Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Dendrite Development Tight Junction Assembly	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division
Pathways			Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		11 interactors: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11	57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		6801	2770
HPRD ID		18124	00756
Ensembl ID		ENSG00000115808	ENSG00000127955
Uniprot IDs		O43815	P63096
PDB IDs			1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of JAK-STAT Cascade Regulation Of Protein Autophosphorylation Inactivation Of MAPK Activity Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Oxidoreductase Activity Negative Regulation Of MAP Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Mitotic Nuclear Envelope Reassembly Regulation Of JAK-STAT Cascade Negative Regulation Of Protein Phosphorylation Nuclear Envelope Reassembly Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Membrane Organization Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Second-messenger-mediated Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Monooxygenase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Nitric Oxide Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Reactive Nitrogen Species Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Protein Kinase Activity Regulation Of Signaling Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Kinase Activity Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Transmembrane Transport Negative Regulation Of Transferase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process
Tagcloud ?			alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?			alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?