STRN and PPP2R1B

Number of citations of the paper that reports this interaction (PMID 18782753)
60

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		STRN	PPP2R1B
Gene Name		striatin, calmodulin binding protein	protein phosphatase 2, regulatory subunit A, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Tight Junction Postsynaptic Density Membrane Neuronal Cell Body Dendritic Spine Postsynaptic Membrane	Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Estrogen Receptor Binding Protein Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Protein Binding
	Biological Process	Locomotory Behavior Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Dendrite Development Tight Junction Assembly	Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by GPCR Integration of energy metabolism Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		11 interactors: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11	31 interactors: AKAP9 ANXA5 BSG CDK1 CDK4 CFTR EEF2 FGFR1OP HDAC1 HSPD1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA SET SGOL1 SGOL2 STRN STRN3
Entrez ID		6801	5519
HPRD ID		18124	04384
Ensembl ID		ENSG00000115808	ENSG00000137713
Uniprot IDs		O43815	P30154
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of JAK-STAT Cascade Regulation Of Protein Autophosphorylation Inactivation Of MAPK Activity Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Oxidoreductase Activity Negative Regulation Of MAP Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Mitotic Nuclear Envelope Reassembly Regulation Of JAK-STAT Cascade Negative Regulation Of Protein Phosphorylation Nuclear Envelope Reassembly Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Membrane Organization Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Second-messenger-mediated Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Monooxygenase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Nitric Oxide Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Reactive Nitrogen Species Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Protein Kinase Activity Regulation Of Signaling Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Kinase Activity Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Transmembrane Transport Negative Regulation Of Transferase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Response To Organic Substance Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Organization Cellular Response To Stimulus Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Ras Protein Signal Transduction Signal Transduction Regulation Of Catalytic Activity Response To Stimulus Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Inorganic Substance Cell Communication Regulation Of Cellular Process MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Reactive Oxygen Species Regulation Of Schwann Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Response To Organic Cyclic Compound Intracellular Signal Transduction Hydrogen Peroxide Metabolic Process Toll-like Receptor Signaling Pathway Response To Oxidative Stress Regulation Of Cell Death Cell Division Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Endomembrane System Organization G2/M Transition Of Mitotic Cell Cycle Response To CAMP Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Metabolic Process Chromosome Organization Activation Of Innate Immune Response Regulation Of Cellular Ketone Metabolic Process Reproduction Response To Organophosphorus
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