BCL2L1 and BAX

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, genetic interference)
HPRD (in vitro, in vivo, two hybrid)

		BCL2L1	BAX
Description		BCL2 like 1	BCL2 associated X, apoptosis regulator
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Synapse Bcl-2 Family Protein Complex	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Pore Complex Extracellular Exosome Cell Periphery Bcl-2 Family Protein Complex BAX Complex BAK Complex
	Molecular Function	Protein Binding Channel Activity Protein Kinase Binding Identical Protein Binding BH3 Domain Binding	Protein Binding Lipid Binding Channel Activity Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein-folding Chaperone Binding BH3 Domain Binding
	Biological Process	Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Response To Stress Mitochondrion Organization Germ Cell Development Spermatogenesis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Response To Radiation Fertilization Response To Virus Negative Regulation Of Autophagy Regulation Of Cytokinesis Positive Regulation Of Mononuclear Cell Proliferation Response To Cytokine Ectopic Germ Cell Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Dendritic Cell Proliferation Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Epithelial Cell Proliferation Negative Regulation Of Developmental Process Neuron Apoptotic Process Defense Response To Virus Response To Other Organism Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Cell Negative Regulation Of Release Of Cytochrome C From Mitochondria Dendritic Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reproductive Process Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Neuron Migration Leukocyte Homeostasis T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process DNA Damage Response Mitochondrion Organization Germ Cell Development Spermatogenesis Nervous System Development Sex Differentiation Mitochondrial Fusion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Response To Wounding Response To Toxic Substance Response To Salt Stress Post-embryonic Development Response To Ionizing Radiation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Mitochondrial Membrane Potential Hypothalamus Development Cerebral Cortex Development Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Developmental Process Protein Insertion Into Mitochondrial Membrane Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Calcium Ion Transport Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Supramolecular Fiber Organization Cellular Response To Virus Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Positive Regulation Of Reproductive Process Positive Regulation Of Motor Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome RAS processing SARS-CoV-1-mediated effects on programmed cell death STAT5 activation downstream of FLT3 ITD mutants NFE2L2 regulating tumorigenic genes	Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor
Drugs		4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Gossypol	TAK-901
Diseases			Colorectal cancer
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Prudent dietary pattern ( 28644415) Putamen volume ( 29147026) Subcortical brain region volumes ( 25607358)	Asthma ( 27611488) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		111 interacting genes: ACTB AKT1 ANTXR1 APAF1 AURKA AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIP5 BNIPL C10orf67 CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CHEK1 CREB3 CRYAA CRYAB CYCS DOCK7 EDRF1 ELOVL4 ERGIC3 FBP1 FKBP8 G0S2 GLOD4 GNLY GOLM1 GORAB GSK3A GSK3B HNRNPA1 HRK IKZF3 IRS1 IRS2 LARP1 MAPK14 MAPK8 MAPK9 MAPKAPK2 MCL1 METTL23 MOAP1 MTIF3 MTNR1B MTOR NLRP1 PARK7 PDIA4 PINK1 PLD3 PLK1 PLK3 PMAIP1 PPHLN1 PPP1CA PRKN PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 REEP4 RHBDD2 RIC3 RNF183 RNF4 RTN1 RTN4 RYR3 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TMEM50B TP53 TP53BP2 TPT1 UBE2I UBR1 UHRF2 VAC14 VDAC1 ZFYVE1 ZHX1 ZNF219	30 interacting genes: ANP32B BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID ERN1 FBXL20 HSF2BP KCNA3 LEF1 MAP2K1 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 TRIM17 UHRF2 USP12 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		598	581
HPRD ID		02497	02498
Ensembl ID		ENSG00000171552	ENSG00000087088
Uniprot IDs		A0A0S2Z3C5 Q07817 Q5TE63	I6LPK7 Q07812 Q5ZPJ0 Q5ZPJ1
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2ME8 2ME9 2MEJ 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4BPK 4C52 4C5D 4CIN 4EHR 4HNJ 4IEH 4PPI 4QVE 4QVF 4QVX 4TUH 4Z9V 5AGW 5AGX 5B1Z 5C3G 5FMJ 5FMK 5VAY 5VX3 6BF2 6DCN 6DCO 6F46 6HJL 6IJQ 6LHD 6O0K 6O0L 6O0M 6O0O 6O0P 6RNU 6ST2 6UVC 6UVD 6UVE 6UVF 6UVG 6UVH 6VWC 6X7I 6YLI 6ZHC 7CA4 7JGV 7JGW 7LH7 7XGF 7XGG 7Y8D 7YAA 8FY0 8IQK 8IQL 8U27 8VWX 8VWZ 8VXM 8VXN 8WLS 8XP5 8ZEB 9AQZ	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII 5W5X 5W5Z 5W60 5W61 6EB6 6L8V 6L95 6TRR 6XY6 7ADT 8G1T 8SPE 8SPF 8SPZ 8SRX 8SRY 8SVK
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Negative Regulation Of Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Mitochondrion Organization Mitochondrial Outer Membrane Intracellular Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Response To Stress Mitochondrion Regulation Of Cellular Response To Stress Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Autophagy Mitochondrial Membrane Organization Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Membrane Permeability Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Mitochondrial Membrane Potential Regulation Of Signaling Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly	Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death DNA Damage Response Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Stress Cellular Response To Stress Mitochondrion Regulation Of Mitochondrial Membrane Potential Intracellular Signal Transduction Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Organelle Organization Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Mitochondrial Membrane
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