BCL2L1 and BAX

Number of citations of the paper that reports this interaction (PMID 9153240)
159

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (two hybrid, in vivo, in vitro)

		BCL2L1	BAX
Gene Name		BCL2-like 1	BCL2-associated X protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Centrosome Cytosol Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Pore Complex Extracellular Vesicular Exosome Bcl-2 Family Protein Complex BAX Complex
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Protein Binding Lipid Binding Channel Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Cytokinesis Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Mitotic Cell Cycle Checkpoint Germ Cell Development Spermatogenesis Cell Proliferation Positive Regulation Of Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Negative Regulation Of Autophagy Suppression By Virus Of Host Apoptotic Process Response To Cytokine Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Neuron Migration T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Germ Cell Development Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic Mitochondrial Changes Fertilization Response To Toxic Substance Response To Salt Stress Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Viral Process Hypothalamus Development Cerebral Cortex Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Oligomerization Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Within A Tissue Protein Oligomerization Protein Homooligomerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Mitochondrion Morphogenesis Cellular Response To Organic Substance Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Retinal Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis	Activation, translocation and oligomerization of BAX Programmed Cell Death Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: ACTB AKT1 ANTXR1 APAF1 AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIPL CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CRYAA CRYAB CYCS DOCK7 EDRF1 FBP1 FKBP8 GLOD4 HRK IKZF3 IRS1 IRS2 LARP1 MAPK8 MCL1 METTL23 MOAP1 MTOR NLRP1 PARK7 PDIA4 PLD3 PMAIP1 PPHLN1 PPP1CA PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 RTN1 RTN4 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TP53 TP53BP2 TPT1 UBR1 UHRF2 VDAC1 ZFYVE1 ZHX1 ZNF219	25 interactors: BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID BNIPL ERN1 KCNA3 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 SNCA UHRF2 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		598	581
HPRD ID		02497	02498
Ensembl ID		ENSG00000171552	ENSG00000087088
Uniprot IDs		Q07817 Q5TE63	Q07812
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4EHR 4HNJ 4IEH	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endopeptidase Activity Zymogen Activation Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Peptidase Activity Negative Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Processing Positive Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Proteolysis Mitochondrial Membrane Organization Positive Regulation Of Organelle Organization Positive Regulation Of Protein Oligomerization Regulation Of Cellular Process Regulation Of Intracellular Transport Mitochondrion Organization	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Release Of Cytochrome C From Mitochondria Mitochondrion Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Signaling Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Endopeptidase Activity Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Regulation Of Peptidase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?		aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal
Tagcloud (Intersection) ?		xl