BCL2L1 and PRKN

Number of citations of the paper that reports this interaction (PubMedID 28038320)
46

Data Source:
BioGRID (enzymatic study, fluorescent resonance energy transfer, affinity chromatography technology)

		BCL2L1	PRKN
Description		BCL2 like 1	parkin RBR E3 ubiquitin protein ligase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Synapse Bcl-2 Family Protein Complex	Golgi Membrane Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Postsynaptic Density Membrane Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Axon Synaptic Vesicle Membrane Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Lewy Body Intracellular Vesicle Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Channel Activity Protein Kinase Binding Identical Protein Binding BH3 Domain Binding	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding Transferase Activity SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Response To Stress Mitochondrion Organization Germ Cell Development Spermatogenesis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Response To Radiation Fertilization Response To Virus Negative Regulation Of Autophagy Regulation Of Cytokinesis Positive Regulation Of Mononuclear Cell Proliferation Response To Cytokine Ectopic Germ Cell Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Dendritic Cell Proliferation Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Epithelial Cell Proliferation Negative Regulation Of Developmental Process Neuron Apoptotic Process Defense Response To Virus Response To Other Organism Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Cell Negative Regulation Of Release Of Cytochrome C From Mitochondria Dendritic Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reproductive Process Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Synaptic Transmission, Dopaminergic Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Autophagy Response To Oxidative Stress Response To Unfolded Protein Mitochondrion Organization Central Nervous System Development Learning Locomotory Behavior Adult Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Response To Muscle Activity Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Anatomical Structure Morphogenesis Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Oxidative Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein K27-linked Ubiquitination Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Protein Stabilization Response To Corticosterone Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Localization Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Necroptotic Process Regulation Of Canonical Wnt Signaling Pathway Type 2 Mitophagy Regulation Of Biological Quality Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Negative Regulation Of Excitatory Postsynaptic Potential Cellular Response To Toxic Substance Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Protein Catabolic Process At Presynapse Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Secretion By Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Cellular Response To L-glutamine Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Cellular Response To L-glutamate Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome RAS processing SARS-CoV-1-mediated effects on programmed cell death STAT5 activation downstream of FLT3 ITD mutants NFE2L2 regulating tumorigenic genes	PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Gossypol
Diseases			Parkinson's disease (PD)
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Prudent dietary pattern ( 28644415) Putamen volume ( 29147026) Subcortical brain region volumes ( 25607358)	Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		111 interacting genes: ACTB AKT1 ANTXR1 APAF1 AURKA AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIP5 BNIPL C10orf67 CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CHEK1 CREB3 CRYAA CRYAB CYCS DOCK7 EDRF1 ELOVL4 ERGIC3 FBP1 FKBP8 G0S2 GLOD4 GNLY GOLM1 GORAB GSK3A GSK3B HNRNPA1 HRK IKZF3 IRS1 IRS2 LARP1 MAPK14 MAPK8 MAPK9 MAPKAPK2 MCL1 METTL23 MOAP1 MTIF3 MTNR1B MTOR NLRP1 PARK7 PDIA4 PINK1 PLD3 PLK1 PLK3 PMAIP1 PPHLN1 PPP1CA PRKN PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 REEP4 RHBDD2 RIC3 RNF183 RNF4 RTN1 RTN4 RYR3 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TMEM50B TP53 TP53BP2 TPT1 UBE2I UBR1 UHRF2 VAC14 VDAC1 ZFYVE1 ZHX1 ZNF219	131 interacting genes: ADRM1 AIMP2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCND1 CDKN1A CHPF COMMD1 COXFA4L2 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EIF4B EPS15 FAF1 FAM120A FBP1 FBXO7 FBXW7 GATA4 GCK GPR37 GRIN2B GTPBP4 HDAC6 HEXD IKBKG LSG1 MDM2 MEOX1 MEOX2 MFN1 MFN2 MRPL13 MRPL19 MRPL45 MTOR NEDD8 NEK2 NKRF NQO1 PA2G4 PAFAH1B2 PDCD2 PHB2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RALY RANBP2 RBCK1 REL RFFL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SF3B2 SF3B3 SIM2 SNCA SNCAIP SRSF1 STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z USP30 USP33 VDAC1 VDR YWHAH ZNF622 ZNF746
Entrez ID		598	5071
HPRD ID		02497	03967
Ensembl ID		ENSG00000171552	ENSG00000185345
Uniprot IDs		A0A0S2Z3C5 Q07817 Q5TE63	O60260 X5DR79
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2ME8 2ME9 2MEJ 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4BPK 4C52 4C5D 4CIN 4EHR 4HNJ 4IEH 4PPI 4QVE 4QVF 4QVX 4TUH 4Z9V 5AGW 5AGX 5B1Z 5C3G 5FMJ 5FMK 5VAY 5VX3 6BF2 6DCN 6DCO 6F46 6HJL 6IJQ 6LHD 6O0K 6O0L 6O0M 6O0O 6O0P 6RNU 6ST2 6UVC 6UVD 6UVE 6UVF 6UVG 6UVH 6VWC 6X7I 6YLI 6ZHC 7CA4 7JGV 7JGW 7LH7 7XGF 7XGG 7Y8D 7YAA 8FY0 8IQK 8IQL 8U27 8VWX 8VWZ 8VXM 8VXN 8WLS 8XP5 8ZEB 9AQZ	1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13 8IK6 8IKV 8JWV 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Negative Regulation Of Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Mitochondrion Organization Mitochondrial Outer Membrane Intracellular Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Response To Stress Mitochondrion Regulation Of Cellular Response To Stress Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Autophagy Mitochondrial Membrane Organization Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Membrane Permeability Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Mitochondrial Membrane Potential Regulation Of Signaling Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly	Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Macromolecule Catabolic Process Cytosol Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Nucleus Protein K48-linked Ubiquitination Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Nucleotide Binding Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Regulation Of Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Nucleoplasm Mitochondrial Outer Membrane Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Proteolysis Cytoplasm Ubiquitin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Mitophagy Transferase Activity Protein Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process
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