BCL2L1 and BNIP1

Number of citations of the paper that reports this interaction (PMID 10217402)
2

Data Source:
HPRD (in vivo, two hybrid)

		BCL2L1	BNIP1
Gene Name		BCL2-like 1	BCL2/adenovirus E1B 19kDa interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Centrosome Cytosol Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex	Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane SNARE Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	SNAP Receptor Activity Protein Binding
	Biological Process	Cytokinesis Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Mitotic Cell Cycle Checkpoint Germ Cell Development Spermatogenesis Cell Proliferation Positive Regulation Of Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Negative Regulation Of Autophagy Suppression By Virus Of Host Apoptotic Process Response To Cytokine Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Autophagy Apoptotic Process Endoplasmic Reticulum Organization Vesicle-mediated Transport Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Apoptotic Process Execution Phase Of Apoptosis
Pathways		Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Infantile hypertrophic pyloric stenosis ( 22306654)
Protein-Protein Interactions		79 interactors: ACTB AKT1 ANTXR1 APAF1 AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIPL CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CRYAA CRYAB CYCS DOCK7 EDRF1 FBP1 FKBP8 GLOD4 HRK IKZF3 IRS1 IRS2 LARP1 MAPK8 MCL1 METTL23 MOAP1 MTOR NLRP1 PARK7 PDIA4 PLD3 PMAIP1 PPHLN1 PPP1CA PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 RTN1 RTN4 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TP53 TP53BP2 TPT1 UBR1 UHRF2 VDAC1 ZFYVE1 ZHX1 ZNF219	6 interactors: APP BCL2 BCL2L1 NAPA NCBP1 STX18
Entrez ID		598	662
HPRD ID		02497	04480
Ensembl ID		ENSG00000171552	ENSG00000113734
Uniprot IDs		Q07817 Q5TE63	Q12981
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4EHR 4HNJ 4IEH
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endopeptidase Activity Zymogen Activation Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Peptidase Activity Negative Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Processing Positive Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Proteolysis Mitochondrial Membrane Organization Positive Regulation Of Organelle Organization Positive Regulation Of Protein Oligomerization Regulation Of Cellular Process Regulation Of Intracellular Transport Mitochondrion Organization	Intracellular Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neuron Apoptotic Process Neuron Death Establishment Of Localization In Cell Cellular Localization Negative Regulation Of Anoikis Regulation Of Anoikis Intracellular Receptor Signaling Pathway Release Of Cytochrome C From Mitochondria Membrane Organization Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Membrane Permeability Regulation Of Cellular Localization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Mitotic Cell Cycle Mitochondrial Membrane Organization Ovarian Follicle Development Apoptotic Mitochondrial Changes Response To Radiation Posttranscriptional Regulation Of Gene Expression Growth MRNA 3'-end Processing Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Vesicle-mediated Transport Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ovulation Cycle Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular PH Reduction CD8-positive, Alpha-beta T Cell Lineage Commitment Apoptotic Process In Bone Marrow Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Multicellular Organism Growth Extrinsic Apoptotic Signaling Pathway RNA 3'-end Processing Regulation Of Autophagy Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Membrane Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Synaptic Growth At Neuromuscular Junction
Tagcloud ?		aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl	adjacent akt1 array bel7402 chemoembolization cytoprotective cytotoxic depletion enhance gadd45a gcb gemcitabine glycoprotein hcc hepatocellular hepatocytes histological parental profiler sclu secretory shrna smmc7721 supported synergistically tnfrsf10a tradd transarterial viability
Tagcloud (Difference) ?		aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized pharmacologic plk1 polo potently recur res rnai top volasertib xl	adjacent akt1 array bel7402 chemoembolization cytoprotective cytotoxic depletion enhance gadd45a gcb gemcitabine glycoprotein hcc hepatocellular hepatocytes histological profiler sclu secretory shrna smmc7721 supported synergistically tnfrsf10a tradd transarterial viability
Tagcloud (Intersection) ?		parental