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BCL2L1 and MTOR
Number of citations of the paper that reports this interaction (PubMedID
20080789
)
23
Data Source:
BioGRID
(enzymatic study)
BCL2L1
MTOR
Description
BCL2 like 1
mechanistic target of rapamycin kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Endoplasmic Reticulum
Centrosome
Cytosol
Cytoskeleton
Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Nuclear Membrane
Mitochondrial Membrane
Synapse
Bcl-2 Family Protein Complex
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Endomembrane System
Membrane
PML Body
Dendrite
Cytoplasmic Vesicle
TORC1 Complex
TORC2 Complex
Phagocytic Vesicle
Serine/threonine Protein Kinase Complex
Molecular Function
Protein Binding
Channel Activity
Protein Kinase Binding
Identical Protein Binding
BH3 Domain Binding
Nucleotide Binding
Inositol Hexakisphosphate Binding
RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding
TFIIIC-class Transcription Factor Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Ribosome Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Biological Process
Ovarian Follicle Development
In Utero Embryonic Development
Release Of Cytochrome C From Mitochondria
Endocytosis
Apoptotic Process
Response To Stress
Mitochondrion Organization
Germ Cell Development
Spermatogenesis
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Response To Radiation
Fertilization
Response To Virus
Negative Regulation Of Autophagy
Regulation Of Cytokinesis
Positive Regulation Of Mononuclear Cell Proliferation
Response To Cytokine
Ectopic Germ Cell Programmed Cell Death
Regulation Of Growth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Dendritic Cell Proliferation
Response To Cycloheximide
Regulation Of Mitochondrial Membrane Permeability
Epithelial Cell Proliferation
Negative Regulation Of Developmental Process
Neuron Apoptotic Process
Defense Response To Virus
Response To Other Organism
Regulation Of Mitochondrial Membrane Potential
Transmembrane Transport
Cellular Response To Amino Acid Stimulus
Cellular Response To Alkaloid
Cellular Response To Gamma Radiation
Apoptotic Process In Bone Marrow Cell
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Dendritic Cell Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Hepatocyte Apoptotic Process
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reproductive Process
Negative Regulation Of Dendritic Cell Apoptotic Process
Negative Regulation Of Anoikis
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Autophagosome Assembly
Regulation Of Cell Growth
Cytoplasmic Translation
T-helper 1 Cell Lineage Commitment
Heart Morphogenesis
Heart Valve Morphogenesis
Energy Reserve Metabolic Process
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
Regulation Of Translational Initiation
Ubiquitin-dependent Protein Catabolic Process
Inflammatory Response
DNA Damage Response
Cytoskeleton Organization
Lysosome Organization
Germ Cell Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Regulation Of Cell Size
Cellular Response To Starvation
Response To Heat
Response To Virus
Post-embryonic Development
Positive Regulation Of Biosynthetic Process
Regulation Of Autophagy
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Myotube Differentiation
Macroautophagy
Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Regulation Of Lipid Metabolic Process
Neuronal Action Potential
Cell Projection Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Actin Filament Polymerization
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Costimulation
Ruffle Organization
Regulation Of Myelination
Protein Destabilization
Response To Nutrient Levels
Cellular Response To Nutrient Levels
Cellular Response To Nutrient
TOR Signaling
Response To Insulin
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Starvation
Multicellular Organism Growth
TORC1 Signaling
TORC2 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Anoikis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Differentiation
Regulation Of Osteoclast Differentiation
Positive Regulation Of Translation
Negative Regulation Of Cell Size
Positive Regulation Of Glycolytic Process
Negative Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase III
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Lipid Biosynthetic Process
Behavioral Response To Pain
Oligodendrocyte Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Cardiac Muscle Tissue Development
Protein Stabilization
Voluntary Musculoskeletal Movement
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Keratinocyte Migration
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Cell Development
Cardiac Muscle Cell Development
Cardiac Muscle Contraction
Cellular Response To Methionine
Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To L-leucine
Cellular Response To Hypoxia
Cellular Response To Osmotic Stress
Regulation Of Cellular Response To Stress
Regulation Of Membrane Permeability
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Antibacterial Innate Immune Response
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of TORC2 Signaling
Regulation Of Locomotor Rhythm
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Cytoplasmic Translational Initiation
Regulation Of Lysosome Organization
Negative Regulation Of Lysosome Organization
Positive Regulation Of Pentose-phosphate Shunt
Cellular Response To Leucine Starvation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cytoplasmic Translation
Regulation Of Autophagosome Assembly
Pathways
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-4 and Interleukin-13 signaling
The NLRP1 inflammasome
RAS processing
SARS-CoV-1-mediated effects on programmed cell death
STAT5 activation downstream of FLT3 ITD mutants
NFE2L2 regulating tumorigenic genes
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
Gossypol
Pimecrolimus
Sirolimus
Everolimus
Rimiducid
SF1126
XL765
Ridaforolimus
Temsirolimus
GSK-1059615
Fostamatinib
Oleandrin
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder (
26184070
)
Platelet count (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Prudent dietary pattern (
28644415
)
Putamen volume (
29147026
)
Subcortical brain region volumes (
25607358
)
A body shape index (
34021172
)
Beard thickness (
26926045
)
Body mass index (
25673413
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Corneal curvature (
24963161
)
Heel bone mineral density (
28869591
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
111 interacting genes:
ACTB
AKT1
ANTXR1
APAF1
AURKA
AVEN
BAD
BAG1
BAK1
BAX
BBC3
BCAP31
BCL2
BCL2L10
BCL2L11
BCL2L12
BCL2L14
BCLAF1
BECN1
BID
BIK
BLK
BMF
BNIP1
BNIP3
BNIP3L
BNIP5
BNIPL
C10orf67
CAPN1
CASP1
CASP8
CASP9
CDKN2A
CFLAR
CHEK1
CREB3
CRYAA
CRYAB
CYCS
DOCK7
EDRF1
ELOVL4
ERGIC3
FBP1
FKBP8
G0S2
GLOD4
GNLY
GOLM1
GORAB
GSK3A
GSK3B
HNRNPA1
HRK
IKZF3
IRS1
IRS2
LARP1
MAPK14
MAPK8
MAPK9
MAPKAPK2
MCL1
METTL23
MOAP1
MTIF3
MTNR1B
MTOR
NLRP1
PARK7
PDIA4
PINK1
PLD3
PLK1
PLK3
PMAIP1
PPHLN1
PPP1CA
PRKN
PSEN1
PSEN2
PTN
RAD9A
RAF1
RBM5
REEP4
RHBDD2
RIC3
RNF183
RNF4
RTN1
RTN4
RYR3
SIVA1
SNCA
SPNS1
TLE1
TMBIM6
TMEM50B
TP53
TP53BP2
TPT1
UBE2I
UBR1
UHRF2
VAC14
VDAC1
ZFYVE1
ZHX1
ZNF219
61 interacting genes:
AKT1
AKT1S1
AMBRA1
BCL2L1
C7orf25
CDC37
CFP
CLIP1
DCP2
EIF3F
EIF4EBP1
EIF4EBP2
EP300
ESR1
FBXO8
FKBP1A
FKBP8
FLNA
GPHN
GSK3B
HRAS
IRS1
MAF1
MAPKAP1
MLST8
NRAS
PA2G4
PCNA
PDPK1
PLD2
PLEKHM1
PPP2R2A
PREX1
PRKAA1
PRKCA
PRKN
PRR5L
RAB1A
RHEB
RHEBL1
RICTOR
RPS6
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
RPTOR
RRAGB
SEPTIN2
SKP2
STAT3
SUMO1
TELO2
TERT
TRAF6
UBQLN1
ULK1
UVRAG
WIPI2
YWHAQ
ZNRF2
Entrez ID
598
2475
HPRD ID
02497
03134
Ensembl ID
ENSG00000171552
ENSG00000198793
Uniprot IDs
A0A0S2Z3C5
Q07817
Q5TE63
A0A8V8TQ52
P42345
PDB IDs
1BXL
1G5J
1LXL
1MAZ
1R2D
1R2E
1R2G
1R2H
1R2I
1YSG
1YSI
1YSN
2B48
2LP8
2LPC
2M03
2M04
2ME8
2ME9
2MEJ
2O1Y
2O2M
2O2N
2P1L
2PON
2YJ1
2YQ6
2YQ7
2YXJ
3CVA
3FDL
3FDM
3INQ
3IO8
3PL7
3QKD
3R85
3SP7
3SPF
3WIZ
3ZK6
3ZLN
3ZLO
3ZLR
4A1U
4A1W
4AQ3
4BPK
4C52
4C5D
4CIN
4EHR
4HNJ
4IEH
4PPI
4QVE
4QVF
4QVX
4TUH
4Z9V
5AGW
5AGX
5B1Z
5C3G
5FMJ
5FMK
5VAY
5VX3
6BF2
6DCN
6DCO
6F46
6HJL
6IJQ
6LHD
6O0K
6O0L
6O0M
6O0O
6O0P
6RNU
6ST2
6UVC
6UVD
6UVE
6UVF
6UVG
6UVH
6VWC
6X7I
6YLI
6ZHC
7CA4
7JGV
7JGW
7LH7
7XGF
7XGG
7Y8D
7YAA
8FY0
8IQK
8IQL
8U27
8VWX
8VWZ
8VXM
8VXN
8WLS
8XP5
8ZEB
9AQZ
1AUE
1FAP
1NSG
2FAP
2GAQ
2NPU
2RSE
3FAP
3JBZ
4DRH
4DRI
4DRJ
4FAP
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5GPG
5H64
5WBH
5WBU
5WBY
5ZCS
6BCU
6BCX
6M4U
6M4W
6SB0
6SB2
6ZWM
6ZWO
7EPD
7OWG
7PE7
7PE8
7PE9
7PEA
7PEB
7PEC
7TZO
7UXC
7UXH
8ER6
8ER7
8ERA
8PPZ
8RCH
8RCK
8RCN
9F44
9F45
Enriched GO Terms of Interacting Partners
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Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrion Organization
Negative Regulation Of Apoptotic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Apoptotic Mitochondrial Changes
Mitochondrion Organization
Mitochondrial Outer Membrane
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Response To Stress
Mitochondrion
Regulation Of Cellular Response To Stress
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
Regulation Of Mitochondrial Membrane Permeability
Extrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Regulation Of Autophagy
Mitochondrial Membrane Organization
Positive Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Organelle Organization
Regulation Of Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Mitochondrial Membrane Potential
Regulation Of Signaling
Regulation Of Cell Communication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Response To Decreased Oxygen Levels
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein-containing Complex Assembly
TOR Signaling
Intracellular Signal Transduction
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
TORC1 Signaling
Regulation Of Autophagy
Intracellular Signaling Cassette
Regulation Of TOR Signaling
TORC2 Signaling
Autophagosome Assembly
Autophagosome Organization
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cytosol
Regulation Of Apoptotic Process
Cellular Response To Nutrient Levels
Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of TOR Signaling
Regulation Of Signaling
Regulation Of Cell Communication
Vacuole Organization
Cytoplasm
Post-transcriptional Regulation Of Gene Expression
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Autophagy
Regulation Of Translational Initiation
Negative Regulation Of Translational Initiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Translation
Positive Regulation Of Translational Initiation
Insulin Receptor Signaling Pathway
Regulation Of Biological Quality
Protein Kinase Binding
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of TORC1 Signaling
Response To Nutrient Levels
Organelle Organization
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Cell Population Proliferation
Signal Transduction
Positive Regulation Of Cell Growth
Regulation Of Cellular Component Organization
Negative Regulation Of Catabolic Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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Tagcloud (Intersection)
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