BCL2L1 and PARK7

Number of citations of the paper that reports this interaction (PMID 21852238)
13

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		BCL2L1	PARK7
Gene Name		BCL2-like 1	parkinson protein 7
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Centrosome Cytosol Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Plasma Membrane PML Body Axon Cell Body Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Core Promoter Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity MRNA Binding Receptor Binding Copper Ion Binding Protein Binding Transcription Factor Binding Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Glyoxalase III Activity Enzyme Binding Kinase Binding Cytokine Binding Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Mercury Ion Binding Androgen Receptor Binding Peroxiredoxin Activity Repressing Transcription Factor Binding Scaffold Protein Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity
	Biological Process	Cytokinesis Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Mitotic Cell Cycle Checkpoint Germ Cell Development Spermatogenesis Cell Proliferation Positive Regulation Of Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Negative Regulation Of Autophagy Suppression By Virus Of Host Apoptotic Process Response To Cytokine Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Proteolysis Protein Deglycosylation Autophagy Inflammatory Response Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Methylglyoxal Catabolic Process To D-lactate Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Glyoxal Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of TRAIL Receptor Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Membrane Hyperpolarization Negative Regulation Of Cell Death Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Fibril Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Positive Regulation Of L-dopa Decarboxylase Activity Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Androgen Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis
Drugs			Double Oxidized Cysteine
Diseases
GWAS			Celiac disease ( 20190752) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		79 interactors: ACTB AKT1 ANTXR1 APAF1 AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIPL CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CRYAA CRYAB CYCS DOCK7 EDRF1 FBP1 FKBP8 GLOD4 HRK IKZF3 IRS1 IRS2 LARP1 MAPK8 MCL1 METTL23 MOAP1 MTOR NLRP1 PARK7 PDIA4 PLD3 PMAIP1 PPHLN1 PPP1CA PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 RTN1 RTN4 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TP53 TP53BP2 TPT1 UBR1 UHRF2 VDAC1 ZFYVE1 ZHX1 ZNF219	20 interactors: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC HIPK1 NDUFA4 PIAS2 PINK1 PPP2R1A PPP2R1B PTEN SOD1 SUMO1 UBA2 UBE2I
Entrez ID		598	11315
HPRD ID		02497	03961
Ensembl ID		ENSG00000171552	ENSG00000116288
Uniprot IDs		Q07817 Q5TE63	K7ELW0 Q99497
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4EHR 4HNJ 4IEH	1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endopeptidase Activity Zymogen Activation Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Peptidase Activity Negative Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Processing Positive Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Proteolysis Mitochondrial Membrane Organization Positive Regulation Of Organelle Organization Positive Regulation Of Protein Oligomerization Regulation Of Cellular Process Regulation Of Intracellular Transport Mitochondrion Organization	Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Sumoylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cell Death Regulation Of Lymphocyte Apoptotic Process Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Mitochondrion Organization Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process TRAIL-activated Apoptotic Signaling Pathway Regulation Of Membrane Potential Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neuron Death Positive Regulation Of Protein Metabolic Process Membrane Organization Viral Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Metabolic Process Organelle Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Toxic Substance Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization
Tagcloud ?		aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl	account alleviates antioxidant clear completely conversely deficiency dj effectively elusive exerts familial hypersensitivity hypersensitizes importantly interacting interestingly neurons oxidative paradigm paraoxonase parkinson partly pd phenylpyridinium pon2 protects rescues stress
Tagcloud (Difference) ?		aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl	account alleviates antioxidant clear completely conversely deficiency dj effectively elusive exerts familial hypersensitivity hypersensitizes importantly interacting interestingly neurons oxidative paradigm paraoxonase parkinson partly pd phenylpyridinium pon2 protects rescues stress
Tagcloud (Intersection) ?