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STAT1 and FGFR3
Number of citations of the paper that reports this interaction (PubMedID
11294897
)
53
Data Source:
HPRD
(in vitro, in vivo)
STAT1
FGFR3
Description
signal transducer and activator of transcription 1
fibroblast growth factor receptor 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
ISGF3 Complex
RNA Polymerase II Transcription Regulator Complex
Extracellular Region
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Transport Vesicle
Cytoplasmic Vesicle
Receptor Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
CCR5 Chemokine Receptor Binding
Histone Acetyltransferase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Protein Phosphatase 2A Binding
Promoter-specific Chromatin Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Fibroblast Growth Factor Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Nutrient
Blood Circulation
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Negative Regulation Of Angiogenesis
Positive Regulation Of Interferon-alpha Production
Cellular Response To Insulin Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Type II Interferon
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Developmental Process
Response To CAMP
Defense Response To Virus
Type II Interferon-mediated Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Renal Tubule Development
Interleukin-27-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Type II Interferon
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
MAPK Cascade
Skeletal System Development
Ossification
Endochondral Ossification
Chondrocyte Differentiation
Endochondral Bone Growth
Apoptotic Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cell-cell Signaling
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Bone Mineralization
Chondrocyte Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of MAPK Cascade
Negative Regulation Of Developmental Growth
Cartilage Development
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Bone Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Signaling by ALK fusions and activated point mutants
Growth hormone receptor signaling
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Signaling by activated point mutants of FGFR3
t(4;14) translocations of FGFR3
Signaling by FGFR3 in disease
Signaling by FGFR3 fusions in cancer
Drugs
XL999
Pazopanib
Ponatinib
Lenvatinib
Nintedanib
Infigratinib
Fostamatinib
Erdafitinib
Pemigatinib
Futibatinib
Selpercatinib
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
CATSHL syndrome
Multiple myeloma
FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN)
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
Bladder cancer
GWAS
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
26394269
28425483
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Bladder cancer (
20972438
24163127
)
Blood protein levels (
30072576
)
Hip circumference adjusted for BMI (
34021172
)
Metabolite levels (
23823483
)
Urinary bladder cancer (
20348956
)
Interacting Genes
112 interacting genes:
ACTN4
ADRA1B
AIRN
AKT1
ATF3
BMX
BRCA1
CAMK2A
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CEBPA
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIAS2
PIK3CA
PKNOX1
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
43 interacting genes:
ANOS1
ARAP1
ATF3
BORA
C6orf47
CCDC17
CEP126
CHGB
CTSK
EPHA4
ERBB2
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KRT8
NDUFS6
NECTIN1
POLA2
PTK2B
RADIL
RNF130
RPL8
RPS6KA3
SH2B1
SLC25A6
SMG7
SRPK2
STAT1
STAT3
Entrez ID
6772
2261
HPRD ID
02777
00624
Ensembl ID
ENSG00000115415
ENSG00000068078
Uniprot IDs
A0A669KB68
A0A8V8TN81
P42224
F8W9L4
P22607
Q0IJ44
X5D2G8
PDB IDs
1BF5
1YVL
2KA6
3WWT
7NUF
8D3F
1RY7
2LZL
4K33
6LVM
6PNX
7DHL
7YSU
8UDT
8UDU
8UDV
9CD7
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Tyrosine Kinase Activity
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Metabolic Process
Signal Transduction
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Primary Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Positive Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Immune System Process
Protein Kinase Activity
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Immune System Process
Phosphorylation
Protein Phosphorylation
Regulation Of Defense Response
Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Development
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Kinase Activity
Response To Lipid
Defense Response
Response To Peptide
Positive Regulation Of Cell Differentiation
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Neurogenesis
Fibroblast Growth Factor Receptor Binding
Growth Factor Activity
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Division
Type 2 Fibroblast Growth Factor Receptor Binding
Type 1 Fibroblast Growth Factor Receptor Binding
Regulation Of Cell Division
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Motility
Regulation Of Locomotion
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Cell Differentiation
Positive Regulation Of Cell Communication
Cell Surface Receptor Signaling Pathway
Signal Transduction
Lung Development
Mesenchymal Cell Proliferation
Cellular Developmental Process
Positive Regulation Of ERK1 And ERK2 Cascade
Extracellular Space
Regulation Of Signal Transduction
Stem Cell Proliferation
Positive Regulation Of MAP Kinase Activity
Cell Population Proliferation
Heparin Binding
Negative Regulation Of Cardiac Muscle Tissue Development
Positive Regulation Of Stem Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Corticotropin Hormone Secreting Cell Differentiation
Angiogenesis
Positive Regulation Of Cell Migration
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Chemotaxis
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Tagcloud (Difference)
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Tagcloud (Intersection)
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