FGFR3 and HBZ

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FGFR3	HBZ
Gene Name		fibroblast growth factor receptor 3	hemoglobin, zeta
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Transport Vesicle Perinuclear Region Of Cytoplasm	Hemoglobin Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding	Oxygen Transporter Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Morphogenesis Of An Epithelium Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Epidermal Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Central Nervous System Myelination Bone Mineralization Forebrain Development Positive Regulation Of Protein Ubiquitination Somatic Stem Cell Maintenance Chondrocyte Proliferation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Digestive Tract Morphogenesis Negative Regulation Of Developmental Growth Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Inner Ear Receptor Cell Differentiation Bone Morphogenesis Axonogenesis Involved In Innervation Alveolar Secondary Septum Development Lens Fiber Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Epithelial Cell Fate Commitment Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cochlea Development Positive Regulation Of Canonical Wnt Signaling Pathway Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Oxygen Transport Erythrocyte Maturation
Pathways		Signaling by FGFR in disease Signaling by FGFR3 mutants Signaling by activated point mutants of FGFR3 Signaling by FGFR mutants t(4;14) translocations of FGFR3
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		38 interactors: ARAP1 ATF3 BORA C6orf47 CCDC17 CHGB CTSK EPHA4 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KIAA1377 KRT8 NDUFS6 POLA2 PTK2B RADIL RNF130 RPL8 SH2B1 SLC25A6 SMG7 STAT1 STAT3	15 interactors: APP DOCK8 FGFR3 HBB HBD HNRNPD IKBKG KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 NOTCH2NL SP1 UPF2
Entrez ID		2261	3050
HPRD ID		00624	00794
Ensembl ID		ENSG00000068078
Uniprot IDs		P22607 Q0IJ44	P02008
PDB IDs		1RY7 4K33	1JEB 3W4U
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Insulin Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Division Response To Hormone Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Immune System Process Regulation Of Cell Proliferation Response To Organic Substance Cell-cell Signaling Response To Stress Anatomical Structure Morphogenesis Cell Differentiation Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Anatomical Structure Development Regulation Of Epithelial Cell Migration	Response To Wounding Blood Coagulation Hemostasis Oxygen Transport Regulation Of Body Fluid Levels Wound Healing Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Memory T Cell Proliferation Negative Regulation Of Nodal Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cellular Protein Metabolic Process Nitric Oxide Transport Collateral Sprouting In Absence Of Injury Cell Recognition RNA Metabolic Process Camera-type Eye Morphogenesis MRNA Metabolic Process Positive Regulation Of Protein Metabolic Process Immune System Process Notch Signaling Pathway Developmental Growth Involved In Morphogenesis Response To Stress Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Transcription, DNA-templated Liver Development Regulation Of Nitrogen Compound Metabolic Process Eye Morphogenesis Alveolar Secondary Septum Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Determination Of Left/right Asymmetry In Lateral Mesoderm Circadian Regulation Of Translation Regulation Of Nodal Signaling Pathway Axonogenesis Involved In Innervation Axon Choice Point Recognition RNA Catabolic Process Cell Activation Platelet Activation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression
Tagcloud ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	acted antisense aph appreciate atl barbeau behave bzip coimmunoprecipitation differently doi halin htert htlv intriguing jun junb jund jvi landry larocque marriott nonpathogenic retroviruses seemingly solely switzer transactivation virol
Tagcloud (Difference) ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	acted antisense aph appreciate atl barbeau behave bzip coimmunoprecipitation differently doi halin htert htlv intriguing jun junb jund jvi landry larocque marriott nonpathogenic retroviruses seemingly solely switzer transactivation virol
Tagcloud (Intersection) ?