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FGFR3 and GTF3C1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
FGFR3
GTF3C1
Gene Name
fibroblast growth factor receptor 3
general transcription factor IIIC, polypeptide 1, alpha 220kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Nucleus
Lysosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Transport Vesicle
Perinuclear Region Of Cytoplasm
Transcription Factor TFIIIC Complex
Nucleus
Nucleoplasm
Nucleolus
Membrane
Ribonucleoprotein Complex
Molecular Function
Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Fibroblast Growth Factor Binding
DNA Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
MAPK Cascade
Skeletal System Development
Positive Regulation Of Endothelial Cell Proliferation
Endochondral Ossification
Morphogenesis Of An Epithelium
Chondrocyte Differentiation
Lens Morphogenesis In Camera-type Eye
Endochondral Bone Growth
Epidermal Growth Factor Receptor Signaling Pathway
JAK-STAT Cascade
Cell-cell Signaling
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Peptidyl-tyrosine Phosphorylation
Substantia Nigra Development
Central Nervous System Myelination
Bone Mineralization
Forebrain Development
Positive Regulation Of Protein Ubiquitination
Somatic Stem Cell Maintenance
Chondrocyte Proliferation
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Cell Differentiation
Negative Regulation Of Mitotic Nuclear Division
Negative Regulation Of Smoothened Signaling Pathway
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Digestive Tract Morphogenesis
Negative Regulation Of Developmental Growth
Response To Axon Injury
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Inner Ear Receptor Cell Differentiation
Bone Morphogenesis
Axonogenesis Involved In Innervation
Alveolar Secondary Septum Development
Lens Fiber Cell Development
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Epithelial Cell Fate Commitment
Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Cochlea Development
Positive Regulation Of Canonical Wnt Signaling Pathway
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Transcription, DNA-templated
Transcription From RNA Polymerase III Promoter
RRNA Transcription
TRNA Transcription
Gene Expression
5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter
TRNA Transcription From RNA Polymerase III Promoter
Pathways
Signaling by FGFR in disease
Signaling by FGFR3 mutants
Signaling by activated point mutants of FGFR3
Signaling by FGFR mutants
t(4;14) translocations of FGFR3
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS
Bladder cancer (
20972438
)
Urinary bladder cancer (
20348956
)
Protein-Protein Interactions
38 interactors:
ARAP1
ATF3
BORA
C6orf47
CCDC17
CHGB
CTSK
EPHA4
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KIAA1377
KRT8
NDUFS6
POLA2
PTK2B
RADIL
RNF130
RPL8
SH2B1
SLC25A6
SMG7
STAT1
STAT3
21 interactors:
AGTRAP
AKTIP
ASCC2
CHN1
CMTM5
CPE
CSNK1E
DEDD
EZH2
FGFR3
GTF3C4
HGH1
IGFBP3
KLF6
MAGEA4
MAPK10
NHP2L1
PRPF38A
RBM23
SUPT5H
TBC1D17
Entrez ID
2261
2975
HPRD ID
00624
07540
Ensembl ID
ENSG00000068078
ENSG00000077235
Uniprot IDs
P22607
Q0IJ44
Q12789
PDB IDs
1RY7
4K33
Enriched GO Terms of Interacting Partners
?
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphatidylinositol-mediated Signaling
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Response To Insulin
Fc-epsilon Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Peptide Hormone
Cellular Response To Organonitrogen Compound
Fc Receptor Signaling Pathway
Response To Peptide
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Hormone Stimulus
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Division
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Response To Organonitrogen Compound
Regulation Of Immune Response
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Cell Division
Response To Hormone
Immune Response
Regulation Of Immune System Process
Defense Response
Positive Regulation Of Cell Proliferation
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Immune System Process
Regulation Of Cell Proliferation
Response To Organic Substance
Cell-cell Signaling
Response To Stress
Anatomical Structure Morphogenesis
Cell Differentiation
Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cell Surface Receptor Signaling Pathway
Anatomical Structure Development
Regulation Of Epithelial Cell Migration
Positive Regulation Of Metabolic Process
Regulation Of Circadian Rhythm
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Catalytic Activity
Regulation Of Muscle Cell Differentiation
MRNA Processing
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Myoblast Differentiation
Positive Regulation Of Phosphorylation
Negative Regulation Of Muscle Cell Differentiation
RNA Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Regulation Of DNA-templated Transcription, Elongation
MRNA Metabolic Process
RNA Processing
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Cellular Metabolic Process
Regulation Of MAPK Cascade
Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Phosphorylation
Cell Surface Receptor Signaling Pathway
Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Regulation Of Gliogenesis
Heterocycle Metabolic Process
Extrinsic Apoptotic Signaling Pathway
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Insulin Processing
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Alveolar Secondary Septum Development
5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter
TRNA Transcription From RNA Polymerase III Promoter
JUN Phosphorylation
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Axonogenesis Involved In Innervation
Tagcloud
?
accrue
alterations
amplified
approved
braf
carry
cdkn2a
copy
cscc
csccs
cutaneous
deleted
drivers
fda
genomic
genomically
guide
inferior
metastasize
metastatic
neck
notch1
oncogenic
pik3ca
recurrently
rtk
sccs
squamous
varying
Tagcloud (Difference)
?
accrue
alterations
amplified
approved
braf
carry
cdkn2a
copy
cscc
csccs
cutaneous
deleted
drivers
fda
genomic
genomically
guide
inferior
metastasize
metastatic
neck
notch1
oncogenic
pik3ca
recurrently
rtk
sccs
squamous
varying
Tagcloud (Intersection)
?