FGFR3 and FGF7

Number of citations of the paper that reports this interaction (PMID 8663044)
243

Data Source:
HPRD (in vitro)

		FGFR3	FGF7
Gene Name		fibroblast growth factor receptor 3	fibroblast growth factor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Transport Vesicle Perinuclear Region Of Cytoplasm	Extracellular Region Golgi Apparatus
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Morphogenesis Of An Epithelium Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Epidermal Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Central Nervous System Myelination Bone Mineralization Forebrain Development Positive Regulation Of Protein Ubiquitination Somatic Stem Cell Maintenance Chondrocyte Proliferation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Digestive Tract Morphogenesis Negative Regulation Of Developmental Growth Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Inner Ear Receptor Cell Differentiation Bone Morphogenesis Axonogenesis Involved In Innervation Alveolar Secondary Septum Development Lens Fiber Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Epithelial Cell Fate Commitment Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cochlea Development Positive Regulation Of Canonical Wnt Signaling Pathway Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth
Pathways		Signaling by FGFR in disease Signaling by FGFR3 mutants Signaling by activated point mutants of FGFR3 Signaling by FGFR mutants t(4;14) translocations of FGFR3	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FGFR2 ligand binding and activation FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)	Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Protein-Protein Interactions		38 interactors: ARAP1 ATF3 BORA C6orf47 CCDC17 CHGB CTSK EPHA4 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KIAA1377 KRT8 NDUFS6 POLA2 PTK2B RADIL RNF130 RPL8 SH2B1 SLC25A6 SMG7 STAT1 STAT3	13 interactors: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 UBQLN1
Entrez ID		2261	2252
HPRD ID		00624	01022
Ensembl ID		ENSG00000068078
Uniprot IDs		P22607 Q0IJ44	P21781 Q6FGV5
PDB IDs		1RY7 4K33
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Insulin Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Division Response To Hormone Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Immune System Process Regulation Of Cell Proliferation Response To Organic Substance Cell-cell Signaling Response To Stress Anatomical Structure Morphogenesis Cell Differentiation Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Anatomical Structure Development Regulation Of Epithelial Cell Migration	Cellular Response To Growth Factor Stimulus Response To Growth Factor Tissue Development Extracellular Matrix Disassembly Cellular Response To Organonitrogen Compound Cellular Response To Organic Substance Skeletal System Morphogenesis Axonogenesis Bone Morphogenesis Ossification Skeletal System Development Endochondral Ossification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Organ Morphogenesis Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Embryo Development Cell Morphogenesis Involved In Differentiation Collagen Catabolic Process Inner Ear Development Response To Organic Substance Regulation Of ERK1 And ERK2 Cascade Cartilage Development Neurotrophin TRK Receptor Signaling Pathway Head Development Neuron Projection Development Collagen Metabolic Process Otic Vesicle Development Neurotrophin Signaling Pathway Response To Organonitrogen Compound Cell Projection Morphogenesis Bone Development Endochondral Bone Morphogenesis Regulation Of Signal Transduction Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Ear Development Cell Part Morphogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Connective Tissue Development Blood Vessel Development Vasculature Development Peptidyl-tyrosine Phosphorylation Inner Ear Morphogenesis Neuron Development Central Nervous System Development
Tagcloud ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Difference) ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
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