FGFR3 and SMG7

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FGFR3	SMG7
Description		fibroblast growth factor receptor 3	SMG7 nonsense mediated mRNA decay factor
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Cell Surface Membrane Transport Vesicle Cytoplasmic Vesicle Receptor Complex	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding Identical Protein Binding	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	MAPK Cascade Skeletal System Development Ossification Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Apoptotic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Mineralization Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Developmental Growth Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation
Pathways		Signaling by activated point mutants of FGFR3 t(4;14) translocations of FGFR3 Signaling by FGFR3 in disease Signaling by FGFR3 fusions in cancer	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib
Diseases		CATSHL syndrome Multiple myeloma FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Bladder cancer
GWAS		Bladder cancer ( 20972438 24163127) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)	Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 26502338 27399966 28714469)
Interacting Genes		43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3	7 interacting genes: FGFR3 GSK3A GSK3B MDM2 RAD17 SIRPA SMG5
Entrez ID		2261	9887
HPRD ID		00624	10723
Ensembl ID		ENSG00000068078	ENSG00000116698
Uniprot IDs		F8W9L4 P22607 Q0IJ44 X5D2G8	A0A8I5KSL3 A0A8I5KYV3 E9PD50 Q6TV06 Q92540
PDB IDs		1RY7 2LZL 4K33 6LVM 6PNX 7DHL 7YSU 8UDT 8UDU 8UDV 9CD7	1YA0
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Fibroblast Growth Factor Receptor Binding Growth Factor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division Type 2 Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Regulation Of Cell Division Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Lung Development Mesenchymal Cell Proliferation Cellular Developmental Process Positive Regulation Of ERK1 And ERK2 Cascade Extracellular Space Regulation Of Signal Transduction Stem Cell Proliferation Positive Regulation Of MAP Kinase Activity Cell Population Proliferation Heparin Binding Negative Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Stem Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Corticotropin Hormone Secreting Cell Differentiation Angiogenesis Positive Regulation Of Cell Migration Regulation Of Anatomical Structure Morphogenesis Regulation Of Chemotaxis	Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Proteasomal Protein Catabolic Process Protein Kinase A Catalytic Subunit Binding Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Tau-protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heart Valve Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Phosphorus Metabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Biosynthetic Process Regulation Of Protein Export From Nucleus Regulation Of Glycogen Metabolic Process Tau Protein Binding Negative Regulation Of Cell Development Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Cell Adhesion Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Developmental Growth
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