FGFR3 and NDUFS6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FGFR3	NDUFS6
Description		fibroblast growth factor receptor 3	NADH:ubiquinone oxidoreductase subunit S6
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Cell Surface Membrane Transport Vesicle Cytoplasmic Vesicle Receptor Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding Identical Protein Binding	NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	MAPK Cascade Skeletal System Development Ossification Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Apoptotic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Mineralization Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Developmental Growth Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Kidney Development Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Mitochondrion Organization Aerobic Respiration Gene Expression Stem Cell Division Respiratory Electron Transport Chain DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Respiratory Chain Complex I Assembly Multicellular Organism Growth Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Mitochondrial Membrane Potential Reproductive System Development Circulatory System Development Mesenchymal Stem Cell Differentiation Reactive Oxygen Species Metabolic Process Cellular Senescence Mesenchymal Stem Cell Proliferation Proton Transmembrane Transport
Pathways		Signaling by activated point mutants of FGFR3 t(4;14) translocations of FGFR3 Signaling by FGFR3 in disease Signaling by FGFR3 fusions in cancer	Respiratory electron transport Complex I biogenesis
Drugs		XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib	NADH
Diseases		CATSHL syndrome Multiple myeloma FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Bladder cancer	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Bladder cancer ( 20972438 24163127) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)	Lack of perseverance ( 30718321) Metabolite levels ( 23823483)
Interacting Genes		43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3	5 interacting genes: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2
Entrez ID		2261	4726
HPRD ID		00624	10356
Ensembl ID		ENSG00000068078	ENSG00000145494
Uniprot IDs		F8W9L4 P22607 Q0IJ44 X5D2G8	O75380 Q6IBC4
PDB IDs		1RY7 2LZL 4K33 6LVM 6PNX 7DHL 7YSU 8UDT 8UDU 8UDV 9CD7	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Fibroblast Growth Factor Receptor Binding Growth Factor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division Type 2 Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Regulation Of Cell Division Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Lung Development Mesenchymal Cell Proliferation Cellular Developmental Process Positive Regulation Of ERK1 And ERK2 Cascade Extracellular Space Regulation Of Signal Transduction Stem Cell Proliferation Positive Regulation Of MAP Kinase Activity Cell Population Proliferation Heparin Binding Negative Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Stem Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Corticotropin Hormone Secreting Cell Differentiation Angiogenesis Positive Regulation Of Cell Migration Regulation Of Anatomical Structure Morphogenesis Regulation Of Chemotaxis	MAPK Cascade Protein Kinase Activity MAP Kinase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signaling Cassette Transferase Activity Positive Regulation Of Signaling Scaffold Protein Binding Protein Serine/threonine Kinase Activity Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity Positive Regulation Of Androgen Receptor Signaling Pathway JNK Cascade Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Smooth Muscle Cell Migration Transcription Coactivator Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Kinase Binding Positive Regulation Of Smooth Muscle Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Heart Rate By Hormone Septin Cytoskeleton Negative Regulation Of Protein Autoubiquitination Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex ATP Binding Bone Maturation Regulation Of Biological Quality Negative Regulation Of Signal Transduction Cellular Response To Hypoxia I-kappaB Phosphorylation Linear Polyubiquitin Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Cellular Response To Decreased Oxygen Levels Positive Regulation Of Phospholipase Activity Regulation Of Protein Modification Process
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