FGFR3 and FGF8

Number of citations of the paper that reports this interaction (PubMedID 10574949)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		FGFR3	FGF8
Description		fibroblast growth factor receptor 3	fibroblast growth factor 8
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Cell Surface Membrane Transport Vesicle Cytoplasmic Vesicle Receptor Complex	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding Identical Protein Binding	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity Chemoattractant Activity
	Biological Process	MAPK Cascade Skeletal System Development Ossification Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Apoptotic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Mineralization Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Developmental Growth Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	MAPK Cascade Branching Involved In Blood Vessel Morphogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Mesonephros Development Neural Plate Morphogenesis Heart Looping Blood Vessel Remodeling Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Apoptotic Process Response To Oxidative Stress Signal Transduction Determination Of Left/right Symmetry Gastrulation Heart Development Motor Neuron Axon Guidance Mesodermal Cell Migration Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gonad Development Fibroblast Growth Factor Receptor Signaling Pathway Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Telencephalon Development Pallium Development Subpallium Development Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Forebrain Neuron Development Central Nervous System Neuron Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Lung Development Regulation Of Cell Migration Male Genitalia Development Thyroid Gland Development Otic Vesicle Formation Midbrain-hindbrain Boundary Development Dorsal/ventral Axon Guidance Embryonic Heart Tube Development Limb Morphogenesis Embryonic Hindlimb Morphogenesis Organ Growth Aorta Morphogenesis Inner Ear Morphogenesis Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Generation Of Neurons Embryonic Neurocranium Morphogenesis Forebrain Morphogenesis Positive Chemotaxis Neuron Apoptotic Process Positive Regulation Of Cell Division Negative Regulation Of Cardiac Muscle Tissue Development Pharyngeal System Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Bone Development Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Dopaminergic Neuron Differentiation Stem Cell Proliferation Cell Migration Involved In Mesendoderm Migration Larynx Morphogenesis Mitotic Nuclear Division Positive Regulation Of Stem Cell Proliferation
Pathways		Signaling by activated point mutants of FGFR3 t(4;14) translocations of FGFR3 Signaling by FGFR3 in disease Signaling by FGFR3 fusions in cancer	Formation of the posterior neural plate
Drugs		XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib
Diseases		CATSHL syndrome Multiple myeloma FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Bladder cancer	Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Bladder cancer ( 20972438 24163127) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)	General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Systolic blood pressure ( 30578418)
Interacting Genes		43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3	5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3
Entrez ID		2261	2253
HPRD ID		00624	02727
Ensembl ID		ENSG00000068078	ENSG00000107831
Uniprot IDs		F8W9L4 P22607 Q0IJ44 X5D2G8	A0A087X1S5 A1A515 P55075
PDB IDs		1RY7 2LZL 4K33 6LVM 6PNX 7DHL 7YSU 8UDT 8UDU 8UDV 9CD7	2FDB
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Fibroblast Growth Factor Receptor Binding Growth Factor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division Type 2 Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Regulation Of Cell Division Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Lung Development Mesenchymal Cell Proliferation Cellular Developmental Process Positive Regulation Of ERK1 And ERK2 Cascade Extracellular Space Regulation Of Signal Transduction Stem Cell Proliferation Positive Regulation Of MAP Kinase Activity Cell Population Proliferation Heparin Binding Negative Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Stem Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Corticotropin Hormone Secreting Cell Differentiation Angiogenesis Positive Regulation Of Cell Migration Regulation Of Anatomical Structure Morphogenesis Regulation Of Chemotaxis	Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Lipase Activity Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Receptor Complex Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Catalytic Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Biomineral Tissue Development Lung-associated Mesenchyme Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Protein Kinase Activity Branching Involved In Salivary Gland Morphogenesis Regulation Of Catalytic Activity Heparin Binding Kinase Activity Bone Growth Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Extracellular Region Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Positive Regulation Of Cell Population Proliferation Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth
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