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FGFR3 and KIAA1377
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
FGFR3
KIAA1377
Gene Name
fibroblast growth factor receptor 3
KIAA1377
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Nucleus
Lysosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Transport Vesicle
Perinuclear Region Of Cytoplasm
Cytoplasm
Centrosome
Midbody
Ciliary Base
Molecular Function
Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Fibroblast Growth Factor Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
MAPK Cascade
Skeletal System Development
Positive Regulation Of Endothelial Cell Proliferation
Endochondral Ossification
Morphogenesis Of An Epithelium
Chondrocyte Differentiation
Lens Morphogenesis In Camera-type Eye
Endochondral Bone Growth
Epidermal Growth Factor Receptor Signaling Pathway
JAK-STAT Cascade
Cell-cell Signaling
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Peptidyl-tyrosine Phosphorylation
Substantia Nigra Development
Central Nervous System Myelination
Bone Mineralization
Forebrain Development
Positive Regulation Of Protein Ubiquitination
Somatic Stem Cell Maintenance
Chondrocyte Proliferation
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Cell Differentiation
Negative Regulation Of Mitotic Nuclear Division
Negative Regulation Of Smoothened Signaling Pathway
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Digestive Tract Morphogenesis
Negative Regulation Of Developmental Growth
Response To Axon Injury
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Inner Ear Receptor Cell Differentiation
Bone Morphogenesis
Axonogenesis Involved In Innervation
Alveolar Secondary Septum Development
Lens Fiber Cell Development
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Epithelial Cell Fate Commitment
Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Cochlea Development
Positive Regulation Of Canonical Wnt Signaling Pathway
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Mitotic Spindle Organization
Cytoplasmic Microtubule Organization
Cilium Assembly
Pathways
Signaling by FGFR in disease
Signaling by FGFR3 mutants
Signaling by activated point mutants of FGFR3
Signaling by FGFR mutants
t(4;14) translocations of FGFR3
Drugs
Diseases
GWAS
Bladder cancer (
20972438
)
Urinary bladder cancer (
20348956
)
Protein-Protein Interactions
38 interactors:
ARAP1
ATF3
BORA
C6orf47
CCDC17
CHGB
CTSK
EPHA4
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KIAA1377
KRT8
NDUFS6
POLA2
PTK2B
RADIL
RNF130
RPL8
SH2B1
SLC25A6
SMG7
STAT1
STAT3
86 interactors:
AIMP2
AKTIP
ARIH2
ATP6V1F
ATRX
BMI1
BRD1
C11orf58
CDKN2B
CRCT1
CSTF2
DGCR6
DISC1
DLEU1
DNM1
DUSP12
DUSP23
EIF2S2
EIF6
EPN1
FAM118B
FAM134A
FEZ1
FGFR3
FXR1
GEMIN7
GET4
GIT1
GOLGB1
GPRASP2
GSTO1
HMOX2
HTT
ING5
KAT5
KAT7
KIF15
KLHL20
LAMTOR5
LPL
LRRC1
LUC7L2
MAD2L1BP
MAPK9
MRPS6
NAP1L5
NAT9
NPM3
NSF
NUDT21
ODF2L
OFD1
PBK
PDCD5
PFDN1
PIK3R3
PMF1
POLD1
POLR2M
PPP1CA
PPP1CC
PRKRA
PTPRS
RAB27A
RAN
RBM23
RGS2
RIF1
ROGDI
RPA2
RUVBL1
SAT1
SNRPG
SPDL1
STAU2
TFG
TNFRSF14
TNFSF11
TOMM20
TTR
TXNDC9
VIM
YAE1D1
YWHAZ
ZBED8
ZNF24
Entrez ID
2261
57562
HPRD ID
00624
17212
Ensembl ID
ENSG00000068078
ENSG00000110318
Uniprot IDs
P22607
Q0IJ44
Q9P2H0
PDB IDs
1RY7
4K33
Enriched GO Terms of Interacting Partners
?
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphatidylinositol-mediated Signaling
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Response To Insulin
Fc-epsilon Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Peptide Hormone
Cellular Response To Organonitrogen Compound
Fc Receptor Signaling Pathway
Response To Peptide
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Hormone Stimulus
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Division
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Response To Organonitrogen Compound
Regulation Of Immune Response
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Cell Division
Response To Hormone
Immune Response
Regulation Of Immune System Process
Defense Response
Positive Regulation Of Cell Proliferation
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Immune System Process
Regulation Of Cell Proliferation
Response To Organic Substance
Cell-cell Signaling
Response To Stress
Anatomical Structure Morphogenesis
Cell Differentiation
Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cell Surface Receptor Signaling Pathway
Anatomical Structure Development
Regulation Of Epithelial Cell Migration
Organelle Organization
Cell Cycle
Mitotic Cell Cycle
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Protein Acetylation
Cellular Metabolic Process
Mitotic Cell Cycle Process
Cellular Process
Response To Light Stimulus
Response To Radiation
Triglyceride Catabolic Process
Gene Expression
Positive Regulation Of Apoptotic Signaling Pathway
Organelle Localization
Acylglycerol Catabolic Process
Endomembrane System Organization
Establishment Of Organelle Localization
Cell Cycle Process
Positive Regulation Of Signal Transduction
Peptidyl-lysine Modification
Endosome Organization
Protein Localization To Organelle
Positive Regulation Of Metabolic Process
Anatomical Structure Development
System Development
Regulation Of Signal Transduction
Termination Of RNA Polymerase II Transcription
Cytoplasmic Transport
Programmed Cell Death
Chromosome Organization
Cell Division
Ribosomal Subunit Export From Nucleus
Cell Death
Regulation Of Signaling
Cellular Response To Stimulus
Death
Histone H3 Acetylation
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Protein Ubiquitination
Mitotic Nuclear Division
Ribonucleoprotein Complex Biogenesis
Response To Abiotic Stimulus
Positive Regulation Of Striated Muscle Contraction
Cellular Response To Organic Substance
RNA Metabolic Process
Organ Development
Neurotransmitter Uptake
Tagcloud
?
accrue
alterations
amplified
approved
braf
carry
cdkn2a
copy
cscc
csccs
cutaneous
deleted
drivers
fda
genomic
genomically
guide
inferior
metastasize
metastatic
neck
notch1
oncogenic
pik3ca
recurrently
rtk
sccs
squamous
varying
Tagcloud (Difference)
?
accrue
alterations
amplified
approved
braf
carry
cdkn2a
copy
cscc
csccs
cutaneous
deleted
drivers
fda
genomic
genomically
guide
inferior
metastasize
metastatic
neck
notch1
oncogenic
pik3ca
recurrently
rtk
sccs
squamous
varying
Tagcloud (Intersection)
?