STAT1 and PDGFRA

Number of citations of the paper that reports this interaction (PMID 9484840)
10

Data Source:
HPRD (in vitro)

		STAT1	PDGFRA
Gene Name		signal transducer and activator of transcription 1, 91kDa	platelet-derived growth factor receptor, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Platelet-derived Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Negative Regulation Of Macrophage Fusion Cellular Response To Interferon-beta Response To Drug Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Renal Tubule Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Estrogen Metabolic Process Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Chemotaxis Cardiac Myofibril Assembly Palate Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Signaling by PDGF Signaling by FGFR in disease ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Signaling by SCF-KIT Downstream signal transduction Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Becaplermin Imatinib Sunitinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Corneal astigmatism ( 22144915) Corneal curvature ( 23401653 21665993) Height ( 18193045) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		103 interactors: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DOT1L DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 ERBB2 FADD FANCC FGFR3 FGFR4 FLT1 FOS FYN GFAP GNB2L1 GTF2I HADH HLA-B HSF1 HSP90AB1 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBC UBE2I VDR XPO1 ZNF467	31 interactors: CAV1 CAV3 CBL CCDC155 CRK CRKL FBXO25 GRB14 ITGAV ITGB3 JAK1 PDGFA PDGFB PDGFC PDGFRB PIK3R1 PLCG1 PTPN11 SHB SHF SLC9A3R1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B TGFBR2 ULBP2
Entrez ID		6772	5156
HPRD ID		02777	01429
Ensembl ID		ENSG00000115415	ENSG00000134853
Uniprot IDs		J3KPM9 P42224	P16234
PDB IDs		1BF5 1YVL 2KA6	1GQ5
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Defense Response Innate Immune Response Response To Cytokine Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Signaling Response To Stress Regulation Of Immune System Process Cell Communication Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Protein Autophosphorylation Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Regulation Of Signaling Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Viral Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signaling Regulation Of Signal Transduction Immune System Process Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Blood Coagulation Positive Regulation Of Protein Metabolic Process Hemostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune System Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Leukocyte Migration Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Protein Phosphorylation Response To Hormone Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast	address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast	address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Intersection) ?