FGFR3 and FGF17

Number of citations of the paper that reports this interaction (PMID 10751172)
45

Data Source:
HPRD (in vitro)

		FGFR3	FGF17
Gene Name		fibroblast growth factor receptor 3	fibroblast growth factor 17
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Transport Vesicle Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Morphogenesis Of An Epithelium Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Epidermal Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Central Nervous System Myelination Bone Mineralization Forebrain Development Positive Regulation Of Protein Ubiquitination Somatic Stem Cell Maintenance Chondrocyte Proliferation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Digestive Tract Morphogenesis Negative Regulation Of Developmental Growth Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Inner Ear Receptor Cell Differentiation Bone Morphogenesis Axonogenesis Involved In Innervation Alveolar Secondary Septum Development Lens Fiber Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Epithelial Cell Fate Commitment Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cochlea Development Positive Regulation Of Canonical Wnt Signaling Pathway Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Signaling by FGFR in disease Signaling by FGFR3 mutants Signaling by activated point mutants of FGFR3 Signaling by FGFR mutants t(4;14) translocations of FGFR3
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		38 interactors: ARAP1 ATF3 BORA C6orf47 CCDC17 CHGB CTSK EPHA4 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KIAA1377 KRT8 NDUFS6 POLA2 PTK2B RADIL RNF130 RPL8 SH2B1 SLC25A6 SMG7 STAT1 STAT3	4 interactors: FGFR1 FGFR2 FGFR3 FGFR4
Entrez ID		2261	8822
HPRD ID		00624	04765
Ensembl ID		ENSG00000068078
Uniprot IDs		P22607 Q0IJ44	O60258
PDB IDs		1RY7 4K33
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Insulin Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Division Response To Hormone Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Immune System Process Regulation Of Cell Proliferation Response To Organic Substance Cell-cell Signaling Response To Stress Anatomical Structure Morphogenesis Cell Differentiation Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Anatomical Structure Development Regulation Of Epithelial Cell Migration	Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Lung Development Respiratory Tube Development Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Respiratory System Development Cell Fate Commitment Response To Insulin Cellular Response To Peptide Hormone Stimulus Lung Alveolus Development Cellular Response To Peptide Ventricular Zone Neuroblast Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Midbrain Development Regulation Of Phospholipase Activity Response To Peptide Positive Regulation Of Lipase Activity Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Lung Saccule Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound
Tagcloud ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?