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STAT1 and SPTAN1
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
36
Data Source:
BioGRID
(two hybrid)
STAT1
SPTAN1
Description
signal transducer and activator of transcription 1
spectrin alpha, non-erythrocytic 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
ISGF3 Complex
RNA Polymerase II Transcription Regulator Complex
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cell Cortex
Spectrin
Microtubule Cytoskeleton
Membrane
Cell Junction
Cortical Actin Cytoskeleton
Specific Granule Lumen
Cell Projection
Extracellular Exosome
Extracellular Vesicle
Tertiary Granule Lumen
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
CCR5 Chemokine Receptor Binding
Histone Acetyltransferase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Protein Phosphatase 2A Binding
Promoter-specific Chromatin Binding
Actin Binding
Structural Constituent Of Cytoskeleton
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Cadherin Binding
Metal Ion Binding
Actin Filament Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Nutrient
Blood Circulation
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Negative Regulation Of Angiogenesis
Positive Regulation Of Interferon-alpha Production
Cellular Response To Insulin Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Type II Interferon
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Developmental Process
Response To CAMP
Defense Response To Virus
Type II Interferon-mediated Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Renal Tubule Development
Interleukin-27-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Type II Interferon
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
Actin Cytoskeleton Organization
Actin Filament Capping
Pathways
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Signaling by ALK fusions and activated point mutants
Growth hormone receptor signaling
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Caspase-mediated cleavage of cytoskeletal proteins
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
RAF/MAP kinase cascade
Neutrophil degranulation
COPI-mediated anterograde transport
RHOU GTPase cycle
RHOV GTPase cycle
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
26394269
28425483
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Axial length (
24144296
)
Body mass index (
26426971
)
Interacting Genes
112 interacting genes:
ACTN4
ADRA1B
AIRN
AKT1
ATF3
BMX
BRCA1
CAMK2A
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CEBPA
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIAS2
PIK3CA
PKNOX1
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
60 interacting genes:
ABI1
ABL1
ACP1
ACTA1
ACTB
AKIP1
ANK1
CAPN1
CASP3
CASP7
CEP63
CREBBP
CTNNA1
DDX24
DES
EPB41
EPB41L2
EPB42
ERCC4
EVL
EXOC1
FANCA
FANCC
GAP43
GRIA2
GRIN1
GRIN2A
GRIN2B
GRIN2D
ITSN1
KALRN
KARS1
MAPK6
NEFL
PCNT
PDE4D
PIN4
PLEC
PLEKHA5
PRKCB
PSMG1
PTEN
PTOV1
SHANK1
SHANK3
SLC9A2
SOS1
SPTB
SPTBN1
SPTBN4
SRC
STAT1
SUMO2
SYN1
TAF1
TANC1
TES
TSSC4
TTC3
ZNF333
Entrez ID
6772
6709
HPRD ID
02777
01684
Ensembl ID
ENSG00000115415
ENSG00000197694
Uniprot IDs
A0A669KB68
A0A8V8TN81
P42224
A0A0D9SF54
A0A0D9SFF6
A0A0D9SGF6
A0A384P5S9
A0A994J6W3
Q13813
PDB IDs
1BF5
1YVL
2KA6
3WWT
7NUF
8D3F
2FOT
3F31
3FB2
5FW9
5FWB
5FWC
6ZEH
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Tyrosine Kinase Activity
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Metabolic Process
Signal Transduction
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Primary Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Positive Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Immune System Process
Protein Kinase Activity
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Immune System Process
Phosphorylation
Protein Phosphorylation
Regulation Of Defense Response
Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Development
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Kinase Activity
Response To Lipid
Defense Response
Response To Peptide
Positive Regulation Of Cell Differentiation
Postsynaptic Density
Structural Constituent Of Cytoskeleton
Cytoskeleton
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Excitatory Postsynaptic Potential
Spectrin
Cytoplasm
Ligand-gated Ion Channel Signaling Pathway
Modulation Of Excitatory Postsynaptic Potential
Glutamate Receptor Signaling Pathway
Cytosol
Cytoskeletal Protein Binding
NMDA Glutamate Receptor Activity
Spectrin-associated Cytoskeleton
NMDA Selective Glutamate Receptor Complex
Glutamate-gated Calcium Ion Channel Activity
Excitatory Chemical Synaptic Transmission
Regulation Of System Process
Glutamatergic Synapse
Ligand-gated Monoatomic Ion Channel Activity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Synapse
Neuromuscular Process
Modulation Of Chemical Synaptic Transmission
Regulation Of Nervous System Process
Cytoskeleton Organization
Neuron Projection
Regulation Of Biological Quality
Ankyrin Binding
Learning Or Memory
Cell Junction
Plasma Membrane
Dendritic Spine
Cell Projection Organization
Associative Learning
Glutamate Binding
Postsynaptic Membrane
Cognition
Regulation Of Neuronal Synaptic Plasticity
Plasma Membrane Bounded Cell Projection Organization
Spectrin Binding
Cortical Cytoskeleton
SH3 Domain Binding
Regulation Of Membrane Potential
Cell Surface Receptor Signaling Pathway
Dendritic Spine Organization
Actin Cytoskeleton Organization
Cell Junction Organization
Cellular Component Assembly
Dendrite
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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