FGFR3 and CTSK

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FGFR3	CTSK
Gene Name		fibroblast growth factor receptor 3	cathepsin K
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Transport Vesicle Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Endolysosome Lumen
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Morphogenesis Of An Epithelium Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Epidermal Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Central Nervous System Myelination Bone Mineralization Forebrain Development Positive Regulation Of Protein Ubiquitination Somatic Stem Cell Maintenance Chondrocyte Proliferation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Digestive Tract Morphogenesis Negative Regulation Of Developmental Growth Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Inner Ear Receptor Cell Differentiation Bone Morphogenesis Axonogenesis Involved In Innervation Alveolar Secondary Septum Development Lens Fiber Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Epithelial Cell Fate Commitment Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cochlea Development Positive Regulation Of Canonical Wnt Signaling Pathway Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Intramembranous Ossification Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Bone Resorption Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Signaling by FGFR in disease Signaling by FGFR3 mutants Signaling by activated point mutants of FGFR3 Signaling by FGFR mutants t(4;14) translocations of FGFR3	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen degradation Activation of Matrix Metalloproteinases MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)	Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		38 interactors: ARAP1 ATF3 BORA C6orf47 CCDC17 CHGB CTSK EPHA4 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KIAA1377 KRT8 NDUFS6 POLA2 PTK2B RADIL RNF130 RPL8 SH2B1 SLC25A6 SMG7 STAT1 STAT3	6 interactors: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		2261	1513
HPRD ID		00624	03064
Ensembl ID		ENSG00000068078	ENSG00000143387
Uniprot IDs		P22607 Q0IJ44	P43235
PDB IDs		1RY7 4K33	1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 7PCK
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Insulin Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Division Response To Hormone Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Immune System Process Regulation Of Cell Proliferation Response To Organic Substance Cell-cell Signaling Response To Stress Anatomical Structure Morphogenesis Cell Differentiation Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Anatomical Structure Development Regulation Of Epithelial Cell Migration	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Somatic Stem Cell Maintenance Platelet Degranulation Regulation Of Endothelial Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway DNA Ligation Involved In DNA Recombination Regulation Of Proteolysis Negative Regulation Of Epithelial Cell Proliferation Cell Activation Response To Wounding Stem Cell Maintenance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Inner Ear Development Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Catalytic Activity Bone Development Ear Development Lagging Strand Elongation Pro-B Cell Differentiation Alveolar Secondary Septum Development Regulation Of Neuron Apoptotic Process Lung Development Axonogenesis Involved In Innervation Stem Cell Development Respiratory Tube Development Response To Abiotic Stimulus Response To Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Respiratory System Development Regulation Of Epithelial Cell Proliferation Regulation Of Neuron Death Immunoglobulin V(D)J Recombination Chondrocyte Proliferation Response To L-ascorbic Acid Establishment Of Viral Latency
Tagcloud ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?