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FGFR3 and HNRNPL
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
FGFR3
HNRNPL
Gene Name
fibroblast growth factor receptor 3
heterogeneous nuclear ribonucleoprotein L
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Nucleus
Lysosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Transport Vesicle
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Ribonucleoprotein Complex
Extracellular Vesicular Exosome
Molecular Function
Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Fibroblast Growth Factor Binding
Nucleotide Binding
RNA Binding
Protein Binding
Transcription Regulatory Region DNA Binding
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
MAPK Cascade
Skeletal System Development
Positive Regulation Of Endothelial Cell Proliferation
Endochondral Ossification
Morphogenesis Of An Epithelium
Chondrocyte Differentiation
Lens Morphogenesis In Camera-type Eye
Endochondral Bone Growth
Epidermal Growth Factor Receptor Signaling Pathway
JAK-STAT Cascade
Cell-cell Signaling
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Peptidyl-tyrosine Phosphorylation
Substantia Nigra Development
Central Nervous System Myelination
Bone Mineralization
Forebrain Development
Positive Regulation Of Protein Ubiquitination
Somatic Stem Cell Maintenance
Chondrocyte Proliferation
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Cell Differentiation
Negative Regulation Of Mitotic Nuclear Division
Negative Regulation Of Smoothened Signaling Pathway
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Digestive Tract Morphogenesis
Negative Regulation Of Developmental Growth
Response To Axon Injury
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Inner Ear Receptor Cell Differentiation
Bone Morphogenesis
Axonogenesis Involved In Innervation
Alveolar Secondary Septum Development
Lens Fiber Cell Development
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Epithelial Cell Fate Commitment
Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Cochlea Development
Positive Regulation Of Canonical Wnt Signaling Pathway
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
MRNA Splicing, Via Spliceosome
RNA Processing
RNA Splicing
Gene Expression
Pathways
Signaling by FGFR in disease
Signaling by FGFR3 mutants
Signaling by activated point mutants of FGFR3
Signaling by FGFR mutants
t(4;14) translocations of FGFR3
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Bladder cancer (
20972438
)
Urinary bladder cancer (
20348956
)
Protein-Protein Interactions
38 interactors:
ARAP1
ATF3
BORA
C6orf47
CCDC17
CHGB
CTSK
EPHA4
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KIAA1377
KRT8
NDUFS6
POLA2
PTK2B
RADIL
RNF130
RPL8
SH2B1
SLC25A6
SMG7
STAT1
STAT3
16 interactors:
APEX1
CSE1L
CSNK2A1
FGFR3
HIST3H3
HMG20B
HMGA1
HNRNPA2B1
HNRNPK
IL7R
ITCH
NEDD4
PCBP2
PJA1
PTBP1
SUMO4
Entrez ID
2261
3191
HPRD ID
00624
04360
Ensembl ID
ENSG00000068078
ENSG00000104824
Uniprot IDs
P22607
Q0IJ44
P14866
Q6NTA2
PDB IDs
1RY7
4K33
3R27
3TO8
Enriched GO Terms of Interacting Partners
?
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphatidylinositol-mediated Signaling
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Response To Insulin
Fc-epsilon Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Peptide Hormone
Cellular Response To Organonitrogen Compound
Fc Receptor Signaling Pathway
Response To Peptide
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Hormone Stimulus
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Division
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Response To Organonitrogen Compound
Regulation Of Immune Response
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Cell Division
Response To Hormone
Immune Response
Regulation Of Immune System Process
Defense Response
Positive Regulation Of Cell Proliferation
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Immune System Process
Regulation Of Cell Proliferation
Response To Organic Substance
Cell-cell Signaling
Response To Stress
Anatomical Structure Morphogenesis
Cell Differentiation
Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cell Surface Receptor Signaling Pathway
Anatomical Structure Development
Regulation Of Epithelial Cell Migration
Negative Regulation Of Cellular Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of MRNA Splicing, Via Spliceosome
RNA Splicing
Negative Regulation Of RNA Splicing
Regulation Of RNA Metabolic Process
Negative Regulation Of Defense Response To Virus
MRNA Processing
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Cellular Metabolic Process
MRNA Metabolic Process
Positive Regulation Of Protein Catabolic Process
Viral Process
Negative Regulation Of Type I Interferon Production
RNA Processing
RNA Metabolic Process
Negative Regulation Of Mitotic Nuclear Division
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription, DNA-templated
Response To Virus
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Transmission Of Virus
Development Involved In Symbiotic Interaction
Catabolic Process
Positive Regulation Of Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Gene Expression
Base-excision Repair
Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Metabolic Process
Nucleobase-containing Compound Metabolic Process
Immune Response
Telomere Maintenance
Negative Regulation Of Gene Expression
Negative Regulation Of Cell Division
Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Interleukin-7-mediated Signaling Pathway
Oncogene-induced Cell Senescence
Regulation Of Defense Response To Virus
Negative Regulation Of Biosynthetic Process
Tagcloud
?
accrue
alterations
amplified
approved
braf
carry
cdkn2a
copy
cscc
csccs
cutaneous
deleted
drivers
fda
genomic
genomically
guide
inferior
metastasize
metastatic
neck
notch1
oncogenic
pik3ca
recurrently
rtk
sccs
squamous
varying
Tagcloud (Difference)
?
accrue
alterations
amplified
approved
braf
carry
cdkn2a
copy
cscc
csccs
cutaneous
deleted
drivers
fda
genomic
genomically
guide
inferior
metastasize
metastatic
neck
notch1
oncogenic
pik3ca
recurrently
rtk
sccs
squamous
varying
Tagcloud (Intersection)
?