TRIM39 and RECK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM39	RECK
Description		tripartite motif containing 39	reversion inducing cysteine rich protein with kazal motifs
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	43 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		56658	8434
HPRD ID		09298	05567
Ensembl ID		ENSG00000204599	ENSG00000122707
Uniprot IDs		A0A024RCP5 Q9HCM9	A8K9D8 O95980 Q6P9E2
PDB IDs		2DID 2DIF 2ECJ	8TZP
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Catabolic Process Nucleus Protein Binding Nucleoplasm Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin Binding Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Modification Process Cysteine-type Deubiquitinase Activity Transferase Activity Protein Deubiquitination Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Negative Regulation Of Protein Deubiquitination ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex DNA Repair Cytosol Protein K6-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process	Keratin Filament Intermediate Filament
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