C3AR1 and C4A

Number of citations: 0 (PubMedID 9725198)
Data Source: HPRD (in vitro)

		C3AR1	C4A
Name		complement C3a receptor 1	complement C4A (Chido/Rodgers blood group)
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Axon Dendrite Cell Projection Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Complement Receptor Activity Complement Component C3a Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity	Complement Binding Complement Component C1q Complex Binding Antigen Binding Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Positive Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Calcium-mediated Signaling Complement Component C5a Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Neutrophil Chemotaxis	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs		None	Human immunoglobulin G
Diseases		None	Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 )	Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Feeling worry ( 29500382 ) Inflammatory bowel disease ( 28067908 ) Neurociticism ( 29500382 ) Neuromyelitis optica ( 29769526 ) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526 ) Prostate cancer ( 23535732 ) Ulcerative colitis ( 28067908 )
Interacting Genes		3 interacting genes: C3 C4A SNTA1	8 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 HSP90AA1 MASP2
Entrez ID		719	720
HPRD ID		05581	00401
Ensembl ID		ENSG00000171860	ENSG00000244731
Uniprot IDs		A8K2H7 Q16581	P0C0L4
PDB IDs		8HK2 8HK3 8I95 8I97 8I9A 8I9L 8I9S 8IA8 8J6D 8JA3	1HZF 5JPM 5JPN 5JTW 6YSQ 7B2M 7B2P 7B2Q
GO Terms Enriched among Interactors		Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Positive Regulation Of Apoptotic Cell Clearance Opsonization Symbiont Cell Surface Antigen Binding Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Complement Activation Positive Regulation Of Phagocytosis Regulation Of Phagocytosis C5L2 Anaphylatoxin Chemotactic Receptor Binding Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Cell Killing Complement-dependent Cytotoxicity Vertebrate Eye-specific Patterning Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Complement-mediated Synapse Pruning Syntrophin Complex Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Endocytosis Protein Maturation Positive Regulation Of Complement Activation Positive Regulation Of Hypersensitivity Complement Binding Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Component C1q Complex Binding Immune Effector Process Synapse Pruning Activation Of Immune Response Nitric-oxide Synthase Binding Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Regulation Of Acute Inflammatory Response To Antigenic Stimulus Dystrophin-associated Glycoprotein Complex Inflammatory Response Regulation Of Vesicle-mediated Transport Ventricular Cardiac Muscle Cell Action Potential	Complement Receptor Activity Complement Receptor Mediated Signaling Pathway Complement Component C4b Binding Complement Component C5a Receptor Activity Activation Of Immune Response Complement Component C5a Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune System Process Response To Stress Regulation Of Neutrophil Chemotaxis Complement Activation, Classical Pathway Defense Response Regulation Of Neutrophil Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Granulocyte Chemotaxis Complement Activation Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Complement Component C3a Receptor Activity Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process CTP Binding DATP Binding Regulation Of Protein Catabolic Process Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Negative Regulation Of Blood Vessel Remodeling Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Extracellular Exosome Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cytokine Production Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cholesterol Import