C3AR1

Name	complement C3a receptor 1
Structure
Interactors	3 interactors: C3 C4A SNTA1
GO Annotations	Cellular Component	Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane
	Molecular Function	Complement Receptor Activity Complement Component C3a Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Positive Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Calcium-mediated Signaling Complement Component C5a Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways	Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade
GWAS	Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 )
Entrez ID	719
HPRD ID	05581
Ensembl ID	ENSG00000171860
Uniprot IDs	A8K2H7 Q16581
PDB IDs	8HK2 8HK3 8I95 8I97 8I9A 8I9L 8I9S 8IA8 8J6D 8JA3
GO Terms Enriched among Interactors ?	Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Positive Regulation Of Apoptotic Cell Clearance Opsonization Symbiont Cell Surface Antigen Binding Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Complement Activation Positive Regulation Of Phagocytosis Regulation Of Phagocytosis C5L2 Anaphylatoxin Chemotactic Receptor Binding Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Cell Killing Complement-dependent Cytotoxicity Vertebrate Eye-specific Patterning Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Complement-mediated Synapse Pruning Syntrophin Complex Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Endocytosis Protein Maturation Positive Regulation Of Complement Activation Positive Regulation Of Hypersensitivity Complement Binding Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Component C1q Complex Binding Immune Effector Process Synapse Pruning Activation Of Immune Response Nitric-oxide Synthase Binding Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Regulation Of Acute Inflammatory Response To Antigenic Stimulus Dystrophin-associated Glycoprotein Complex Inflammatory Response Regulation Of Vesicle-mediated Transport Ventricular Cardiac Muscle Cell Action Potential