SCN1A and SNTA1

Number of citations of the paper that reports this interaction (PMID 9412493)
66

Data Source:
BioGRID (unspecified method)

		SCN1A	SNTA1
Gene Name		sodium channel, voltage gated, type I alpha subunit	syntrophin, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Intercalated Disc Z Disc T-tubule Node Of Ranvier Neuronal Cell Body Axon Initial Segment	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Sodium Ion Transport Adult Walking Behavior Neuronal Action Potential Propagation Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Neuromuscular Process Controlling Posture Membrane Depolarization During Action Potential	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Phenytoin Topiramate Zonisamide Phenacemide Phenazopyridine Nitrazepam Dronedarone Permethrin
Diseases
GWAS		Epilepsy (generalized) ( 22949513)
Protein-Protein Interactions		2 interactors: PSEN1 SNTA1	72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		6323	6640
HPRD ID		01669	03009
Ensembl ID		ENSG00000144285	ENSG00000101400
Uniprot IDs		P35498	B4DX40 Q13424
PDB IDs
Enriched GO Terms of Interacting Partners?		Cajal-Retzius Cell Differentiation Beta-amyloid Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Membrane Potential Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Choline Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Amyloid Precursor Protein Catabolic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Receptor Recycling Negative Regulation Of Cellular Protein Metabolic Process Amyloid Precursor Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Notch Receptor Processing Ventricular Cardiac Muscle Cell Action Potential Myeloid Dendritic Cell Differentiation Regulation Of Membrane Repolarization Negative Regulation Of Receptor Activity Myeloid Dendritic Cell Activation L-glutamate Transport Regulation Of Receptor Recycling Regulation Of Epidermal Growth Factor-activated Receptor Activity Cardiac Muscle Cell Action Potential Involved In Contraction Cerebral Cortex Neuron Differentiation Endoplasmic Reticulum Calcium Ion Homeostasis Dorsal/ventral Neural Tube Patterning Membrane Protein Proteolysis Protein Maturation Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Dendritic Cell Differentiation Positive Regulation Of Coagulation Vesicle Targeting Autophagic Vacuole Assembly Brain Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Skin Morphogenesis Synaptic Vesicle Exocytosis	Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus
Tagcloud ?		chaperones csei defective differently epilepsies epileptogenic exploited fhm folding gated hemiplegic limitations migraine missense mutants nav1 ones overcome pathomechanism pharmacological phenytoin proof rescuable rescue rescued rescuing spread toxin voltage	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Difference) ?		chaperones csei defective differently epilepsies epileptogenic exploited fhm folding gated hemiplegic limitations migraine missense mutants nav1 ones overcome pathomechanism pharmacological phenytoin proof rescuable rescue rescued rescuing spread toxin voltage	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Intersection) ?