SCN1A

Gene Name		sodium channel, voltage gated, type I alpha subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Intercalated Disc Z Disc T-tubule Node Of Ranvier Neuronal Cell Body Axon Initial Segment
	Molecular Function	Voltage-gated Sodium Channel Activity
	Biological Process	Sodium Ion Transport Adult Walking Behavior Neuronal Action Potential Propagation Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Neuromuscular Process Controlling Posture Membrane Depolarization During Action Potential
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Phenytoin Topiramate Zonisamide Phenacemide Phenazopyridine Nitrazepam Dronedarone Permethrin
Diseases
GWAS		Epilepsy (generalized) ( 22949513)
Protein-protein Interactions		2 interactors: PSEN1 SNTA1
Entrez ID		6323
HPRD ID		01669
Ensembl ID		ENSG00000144285
Uniprot IDs		P35498
PDB IDs
Enriched GO Terms of Interacting Partners?		Cajal-Retzius Cell Differentiation Beta-amyloid Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Membrane Potential Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Choline Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Amyloid Precursor Protein Catabolic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Receptor Recycling Negative Regulation Of Cellular Protein Metabolic Process Amyloid Precursor Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Notch Receptor Processing Ventricular Cardiac Muscle Cell Action Potential Myeloid Dendritic Cell Differentiation Regulation Of Membrane Repolarization Negative Regulation Of Receptor Activity Myeloid Dendritic Cell Activation L-glutamate Transport Regulation Of Receptor Recycling Regulation Of Epidermal Growth Factor-activated Receptor Activity Cardiac Muscle Cell Action Potential Involved In Contraction Cerebral Cortex Neuron Differentiation Endoplasmic Reticulum Calcium Ion Homeostasis Dorsal/ventral Neural Tube Patterning Membrane Protein Proteolysis Protein Maturation Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Dendritic Cell Differentiation Positive Regulation Of Coagulation Vesicle Targeting Autophagic Vacuole Assembly Brain Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Skin Morphogenesis Synaptic Vesicle Exocytosis
Tagcloud ?		chaperones csei defective differently epilepsies epileptogenic exploited fhm folding gated hemiplegic limitations migraine missense mutants nav1 ones overcome pathomechanism pharmacological phenytoin proof rescuable rescue rescued rescuing spread toxin voltage