NEDD4 and MARK4

Number of citations of the paper that reports this interaction (PubMedID 19953087)
60

Data Source:
BioGRID (enzymatic study)

		NEDD4	MARK4
Description		NEDD4 E3 ubiquitin protein ligase	microtubule affinity regulating kinase 4
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Apicolateral Plasma Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Channel Inhibitor Activity Transferase Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Ubiquitin Binding Transmembrane Transporter Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Anchor Activity Kinase Activity Transferase Activity Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Lysosome Sodium Ion Transport Immune Response DNA Damage Response Lysosomal Transport Nervous System Development Neuromuscular Junction Development Regulation Of Cell Communication Negative Regulation Of Sodium Ion Transport Regulation Of Macroautophagy Protein Ubiquitination Regulation Of Signaling Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV T Cell Activation Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Formation Of Structure Involved In A Symbiotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Biological Quality Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Nervous System Development Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Centrosome Cycle Microtubule Polymerization Cell Division Cilium Disassembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Centrosome
Pathways		ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Anchoring of the basal body to the plasma membrane
Drugs			Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 24292274 28165464) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278)	Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Granulocyte count ( 27863252) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549) White blood cell count ( 27863252 32888494)
Interacting Genes		282 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AK6 AKT1 AKT3 AMOT AMOTL1 AMPD2 ANK3 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BAIAP2L1 BIRC6 BMPR1A C15orf62 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDIP1 CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CRTC2 CUEDC1 DAZAP2 DCUN1D1 DDN DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EGR1 ENTREP1 EP300 EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 ESS2 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FOXJ3 FYN GABARAP GABARAPL1 GABARAPL2 GBA1 GFUS GJA1 GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HMGCL HNRNPK HNRNPL HNRNPU HNRNPUL1 HRAS IFITM3 IGF1R IL1B IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 KLF5 KRAS LATS1 LDLRAD3 LDLRAD4 LINC01198 LITAF LUC7L2 MAML2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MS4A10 MTMR4 MYCN MYCT1 MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NRAS NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP4P2 PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRR7 PRRG2 PRRG4 PSMD4 PTEN PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RBM14 RET RFT1 RHBDD1 RHBDD2 RNF11 RNF38 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN10A SCN1A SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SQSTM1 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 STRIP2 SULF1 SYK SYNPO2 SYT1 TAF1B TBC1D7 TCEANC TCP11L1 TEAD2 TGFB1I1 THOC1 THRAP3 TMEM139 TMEM252 TMEM51 TNIK TOM1 TOM1L2 TP53BP2 TP63 TP73 TRERF1 TRIM44 TRIM52 TRPV6 TTYH2 TTYH3 TULP4 TUSC2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2L6 UBE2M UBOX5 URI1 UVRAG VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1 ZC3H14	32 interacting genes: AKT1 APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NLRP3 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ
Entrez ID		4734	57787
HPRD ID		03786	09402
Ensembl ID		ENSG00000069869	ENSG00000007047
Uniprot IDs		P46934	Q96L34
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91	5ES1 8XFL
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Phosphorylation Intracellular Signal Transduction ATP Binding Nucleotide Binding Phosphorylation WW Domain Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Serine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Protein Autophosphorylation Signal Transduction Cytoplasm Regulation Of Protein Modification Process Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process MAPK Cascade Positive Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Macromolecule Metabolic Process Positive Regulation Of Cell Communication Apoptotic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Positive Regulation Of Signaling Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Programmed Cell Death Cell Surface Receptor Signaling Pathway Cell Death Regulation Of Apoptotic Process Nucleoplasm Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Projection Organization Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Communication	Microtubule Cytoskeleton Protein Domain Specific Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Phosphoserine Residue Binding Microtubule Regulation Of Cellular Component Organization Cytosol Cytoskeleton Structural Molecule Activity Regulation Of Transport Golgi Localization Organelle Organization Cytoplasm Regulation Of Cellular Localization Tubulin Binding Regulation Of Cell Communication Regulation Of Signaling Cilium Intracellular Protein Localization GTP-dependent Protein Binding Cytoskeleton Organization Extracellular Exosome Regulation Of Neuron Projection Development Positive Regulation Of Transport Regulation Of Synapse Organization Negative Regulation Of Cell Projection Organization Positive Regulation Of Vesicle Transport Along Microtubule Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Supramolecular Fiber Organization Regulation Of Signal Transduction Regulation Of Protein Localization Regulation Of TORC1 Signaling Neuron Projection Main Axon Nuclear Receptor-mediated Corticosteroid Signaling Pathway Structural Constituent Of Cytoskeleton Protein Targeting PAR Polarity Complex Enzyme Binding Regulation Of Cell Growth Microtubule-based Process Establishment Of Golgi Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Microtubule Binding Regulation Of Cell Development Regulation Of Organelle Transport Along Microtubule Transmembrane Transporter Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Nervous System Development
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