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NEDD4 and HGS
Number of citations of the paper that reports this interaction (PubMedID
12230472
)
0
Data Source:
HPRD
(in vitro, in vivo)
NEDD4
HGS
Description
NEDD4 E3 ubiquitin protein ligase
hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Apicolateral Plasma Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Cytosol
Cytoplasm
Lysosome
Endosome
Early Endosome
Cytosol
Membrane
Early Endosome Membrane
Multivesicular Body Membrane
ESCRT-0 Complex
Extracellular Exosome
Phagocytic Vesicle Lumen
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Channel Inhibitor Activity
Transferase Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ionotropic Glutamate Receptor Binding
Ubiquitin Binding
Transmembrane Transporter Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Phosphatidylinositol Binding
Ubiquitin Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Adaptive Immune Response
Outflow Tract Morphogenesis
Endocardial Cushion Development
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Targeting To Lysosome
Sodium Ion Transport
Immune Response
DNA Damage Response
Lysosomal Transport
Nervous System Development
Neuromuscular Junction Development
Regulation Of Cell Communication
Negative Regulation Of Sodium Ion Transport
Regulation Of Macroautophagy
Protein Ubiquitination
Regulation Of Signaling
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
T Cell Activation
Regulation Of Protein Catabolic Process
Regulation Of Membrane Potential
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Formation Of Structure Involved In A Symbiotic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Blood Vessel Morphogenesis
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Establishment Of Localization In Cell
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Biological Quality
Protein K63-linked Ubiquitination
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Protein Targeting To Lysosome
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Membrane Invagination
Positive Regulation Of Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Protein Transport
Endosomal Transport
Macroautophagy
Negative Regulation Of Angiogenesis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Receptor Internalization
Endocytic Recycling
Multivesicular Body Assembly
Regulation Of Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of MAP Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Localization To Membrane
Membrane Fission
Positive Regulation Of Exosomal Secretion
Pathways
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
RHOU GTPase cycle
Endosomal Sorting Complex Required For Transport (ESCRT)
Inhibition of membrane repair
Prevention of phagosomal-lysosomal fusion
RHOBTB3 ATPase cycle
Drugs
Citric acid
Diseases
GWAS
Appendicular lean mass (
33097823
)
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
24292274
28165464
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Eye color traits (
20463881
)
Refractive error (
32231278
)
Interacting Genes
282 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AK6
AKT1
AKT3
AMOT
AMOTL1
AMPD2
ANK3
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BAIAP2L1
BIRC6
BMPR1A
C15orf62
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDIP1
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CRTC2
CUEDC1
DAZAP2
DCUN1D1
DDN
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EGR1
ENTREP1
EP300
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
ESS2
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FOXJ3
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA1
GFUS
GJA1
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HMGCL
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
HRAS
IFITM3
IGF1R
IL1B
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
KLF5
KRAS
LATS1
LDLRAD3
LDLRAD4
LINC01198
LITAF
LUC7L2
MAML2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MS4A10
MTMR4
MYCN
MYCT1
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NRAS
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP4P2
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRR7
PRRG2
PRRG4
PSMD4
PTEN
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RBM14
RET
RFT1
RHBDD1
RHBDD2
RNF11
RNF38
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN10A
SCN1A
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SQSTM1
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
STRIP2
SULF1
SYK
SYNPO2
SYT1
TAF1B
TBC1D7
TCEANC
TCP11L1
TEAD2
TGFB1I1
THOC1
THRAP3
TMEM139
TMEM252
TMEM51
TNIK
TOM1
TOM1L2
TP53BP2
TP63
TP73
TRERF1
TRIM44
TRIM52
TRPV6
TTYH2
TTYH3
TULP4
TUSC2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2L6
UBE2M
UBOX5
URI1
UVRAG
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
ZC3H14
328 interacting genes:
ABI2
ACLY
ACOT11
ACTN3
ADRA2C
AHCYL1
AKAP8L
ANKRD55
ANTKMT
APC
APLP2
APP
ARFIP2
ARL6IP1
ARMC7
ASB12
ATN1
ATP1A1
ATP2A2
ATXN1L
BBC3
BCAS2
BEGAIN
BFSP2
BICRAL
BLOC1S1
BORCS6
BRINP3
BSG
C1orf94
C20orf173
C3orf36
CASK
CBS
CCDC136
CCDC196
CCDC33
CCND3
CDR2
CDSN
CEACAM6
CEP55
CEP57L1
CEP63
CEP68
CFAP68
CIMIP2A
CLTC
COG8
CRMP1
CRX
CSNK2A1
CSTF2
CSTF2T
CTTNBP2NL
CYB5R2
DAAM2
DAZAP2
DCTN2
DECR1
DEUP1
DGCR6
DLG4
DNAAF19
DSN1
DTX2
DYDC1
EFHC2
EGFL7
EGFR
EHMT2
EIF3F
EPS15
ESRRG
EXOC3L1
EXOC5
EXOC7
EXOC8
EYA2
FAM168A
FAM185A
FANCG
FBN1
FCHSD2
FIGN
FLOT1
FLOT2
FNDC11
FOXD4L1
FOXI1
FSD2
FTCD
GATC
GFAP
GFI1B
GGA2
GKAP1
GOLGA2
GOLGA6L9
GOLGA7B
GUCA1C
HAP1
HAUS1
HNRNPDL
HNRNPM
HSF4
HSFY1
HSPA8
ICA1L
IFNA16
IFT74
IL2RB
IL4R
ILKAP
ING5
INTS4
IPO4
JAKMIP2
JMJD7
KIAA0753
KIAA0825
KLF4
KRT13
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
KRT6A
KRT75
KRT76
KRT82
KRT86
KRTAP19-5
KRTAP26-1
KRTAP7-1
LASP1
LDOC1
LINC00265
LITAF
LMO1
LMO4
LRRC61
LURAP1
LYST
MAGEB4
MAGED1
MAP3K1
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED21
MED22
MED25
MED30
MED4
MED7
MEIS3
MEST
MET
METTL27
MIF4GD
MKNK1
MKRN3
MRFAP1L1
MTHFD1L
NADSYN1
NDC80
NDUFB10
NEDD4
NEDD8
NEFL
NF2
NFYC
NMI
NPAS2
NUP54
NUP62
NUTM2F
ODAM
OIP5
OSBPL5
P4HA3
PAK1
PAX5
PAX6
PEF1
PELP1
PFKM
PIK3R1
PITX1
PKNOX2
PLA2G10
PLAAT1
PLCD1
PLD3
PLEKHB2
PMEPA1
PNMA1
POGZ
POU2AF1
POU6F2
PPP1R16A
PPP1R7
PPP2R3B
PRR22
PRR5
PSMB11
PSMB4
PTCD3
RASSF4
RBCK1
RFC2
RFX6
RHOBTB3
RINT1
RNF4
RPRD1A
RPS3A
RSPO4
RSU1
RUNX1
SAPCD1
SAXO4
SCAMP3
SCRN1
SCT
SDS
SERGEF
SERTAD3
SF3B3
SHANK3
SMAD2
SMAD3
SMAD5
SMARCB1
SNAP25
SNX1
SNX5
SNX7
SORBS3
SPATA12
SPC25
SPIRE2
SPMIP6
SS18L1
STAM
STAM2
STK32C
STMN3
STX11
STXBP1
SUMO1
SUN2
SYK
TADA2A
TASOR2
TBX19
TCP11L2
TEKT1
TEKT5
TFG
TIMM10B
TIMMDC1
TJP2
TLE5
TMCC2
TOM1L1
TP53BP1
TRAF1
TRAF4
TRAK1
TRAP1
TRIM10
TRIM17
TRIM23
TRIM27
TRIM54
TRIM69
TRIM73
TRIML2
TSC1
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBAP2
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN4
UBQLNL
UBXN11
USHBP1
USP54
VGLL3
VMP1
VPS37A
VPS37B
VPS37C
VPS37D
VPS52
WASHC1
WWP2
YPEL3
ZNF302
ZNF34
ZNF430
ZNF44
Entrez ID
4734
9146
HPRD ID
03786
05085
Ensembl ID
ENSG00000069869
ENSG00000185359
Uniprot IDs
P46934
A0A0S2Z4R4
O14964
PDB IDs
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
?
Protein Kinase Activity
Kinase Activity
Protein Phosphorylation
Intracellular Signal Transduction
ATP Binding
Nucleotide Binding
Phosphorylation
WW Domain Binding
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Transferase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Serine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Protein Autophosphorylation
Signal Transduction
Cytoplasm
Regulation Of Protein Modification Process
Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
MAPK Cascade
Positive Regulation Of Metabolic Process
Peptidyl-tyrosine Phosphorylation
Macromolecule Metabolic Process
Positive Regulation Of Cell Communication
Apoptotic Process
Intracellular Signaling Cassette
Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cytosol
Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Programmed Cell Death
Cell Surface Receptor Signaling Pathway
Cell Death
Regulation Of Apoptotic Process
Nucleoplasm
Regulation Of Biological Quality
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Projection Organization
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Motility
Regulation Of Locomotion
Regulation Of Cell Communication
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Keratin Filament
Intermediate Filament
Protein Binding
Structural Molecule Activity
Organelle Organization
Epithelial Cell Differentiation
Supramolecular Fiber Organization
Cytoskeleton Organization
Cytoskeleton
Morphogenesis Of An Epithelium
Tissue Morphogenesis
Anatomical Structure Morphogenesis
Cellular Localization
Cytosol
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Membrane Fission
Ubiquitin Protein Ligase Binding
Intracellular Transport
Intracellular Protein Localization
Establishment Of Protein Localization
Axonemal A Tubule Inner Sheath
Microtubule-based Process
Protein Transport
Establishment Of Protein Localization To Vacuole
Structural Constituent Of Cytoskeleton
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Ubiquitin Binding
Establishment Of Localization In Cell
Endosome Transport Via Multivesicular Body Sorting Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
ESCRT I Complex
Protein Localization To Vacuole
Multivesicular Body Assembly
Multivesicular Body Organization
Endosomal Transport
Endosome Membrane
Multivesicular Body Sorting Pathway
Identical Protein Binding
Epidermis Development
Modification-dependent Protein Catabolic Process
Late Endosome To Vacuole Transport
Viral Budding
Protein Tag Activity
Core Mediator Complex
Exocyst
Organelle Localization
Tagcloud
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Tagcloud (Difference)
?
Tagcloud (Intersection)
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