NEDD4 and ERBB4

Number of citations of the paper that reports this interaction (PMID 19193720)
10

Data Source:
BioGRID (enzymatic study)

		NEDD4	ERBB4
Gene Name		neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	erb-b2 receptor tyrosine kinase 4
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Ligase Activity Sodium Channel Inhibitor Activity Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Binding Phosphothreonine Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Protein Monoubiquitination Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Transmission Of Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport T Cell Activation Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Glucocorticoid Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways		Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System
Drugs
Diseases
GWAS		Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 20062064) Keloid ( 20711176)	Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		215 interactors: ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ARRDC1 ARRDC3 ASPSCR1 AURKC BAIAP2 BECN1 BMPR1A BRCA2 C11orf63 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS EPS15 ERBB3 ERBB4 ERMN FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GBA GRB10 GRIN2A GRK4 GRK7 HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IGF1R IRS1 JUN KCNAB1 KCNAB2 KIAA1598 KIFC3 LAPTM5 LATS1 LITAF LUC7L2 MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NTRK1 NUDT21 PARP16 PDGFRB PKN2 PLK1 PLK2 PMEPA1 POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PTEN RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPT9 SFTPC SGK1 SGK2 SH3KBP1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THRAP3 TNIK TOM1 TOM1L2 TP73 TRIM44 TRIM52 TRPV6 TSTA3 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 WBP1 WBP2 WEE1 WIBG YES1 YOD1	39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1
Entrez ID		4734	2066
HPRD ID		03786	02767
Ensembl ID		ENSG00000069869	ENSG00000178568
Uniprot IDs		P46934	Q15303
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Phosphorylation Response To Growth Factor Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cell Communication Cellular Protein Modification Process Regulation Of Phosphorylation Signal Transduction Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Regulation Of Metabolic Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Regulation Of Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cellular Metabolic Process Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade
Tagcloud ?		accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Intersection) ?