NEDD4 and TP73

Number of citations of the paper that reports this interaction (PMID 15678106)
69

Data Source:
HPRD (in vivo)

		NEDD4	TP73
Gene Name		neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	tumor protein p73
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ligase Activity Sodium Channel Inhibitor Activity Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Binding Phosphothreonine Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Protein Monoubiquitination Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Transmission Of Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport T Cell Activation Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Glucocorticoid Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To X-ray Response To Organonitrogen Compound Response To Gamma Radiation Regulation Of Gene Expression Hippocampus Development Mitotic G1 DNA Damage Checkpoint Cerebrospinal Fluid Secretion Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System
Drugs
Diseases
GWAS		Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 20062064) Keloid ( 20711176)	Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		215 interactors: ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ARRDC1 ARRDC3 ASPSCR1 AURKC BAIAP2 BECN1 BMPR1A BRCA2 C11orf63 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS EPS15 ERBB3 ERBB4 ERMN FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GBA GRB10 GRIN2A GRK4 GRK7 HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IGF1R IRS1 JUN KCNAB1 KCNAB2 KIAA1598 KIFC3 LAPTM5 LATS1 LITAF LUC7L2 MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NTRK1 NUDT21 PARP16 PDGFRB PKN2 PLK1 PLK2 PMEPA1 POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PTEN RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPT9 SFTPC SGK1 SGK2 SH3KBP1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THRAP3 TNIK TOM1 TOM1L2 TP73 TRIM44 TRIM52 TRPV6 TSTA3 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 WBP1 WBP2 WEE1 WIBG YES1 YOD1	50 interactors: ABL1 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP DAXX EP300 FBXO45 GNB2L1 HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PML PPP1R13B RANBP9 RBX1 RCHY1 SMAD2 SMAD3 SUMO1 TDG TP53 TP63 UBE2I WT1 WWOX XPO1 YAP1
Entrez ID		4734	7161
HPRD ID		03786	03587
Ensembl ID		ENSG00000069869	ENSG00000078900
Uniprot IDs		P46934	C9J521 O15350
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8	1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Phosphorylation Response To Growth Factor Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cell Communication Cellular Protein Modification Process Regulation Of Phosphorylation Signal Transduction Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Regulation Of Metabolic Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Regulation Of Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cellular Metabolic Process Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification	Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Apoptotic Process Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Regulation Of Signal Transduction Cell Death Cellular Response To Stress Death Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Difference) ?		accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Intersection) ?