NEDD4 and IGF1R

Number of citations of the paper that reports this interaction (PubMedID 12697834)
63

Data Source:
HPRD (in vivo)

		NEDD4	IGF1R
Description		NEDD4 E3 ubiquitin protein ligase	insulin like growth factor 1 receptor
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Apicolateral Plasma Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol	Nucleolus Plasma Membrane Insulin Receptor Complex Cilium Membrane Axon Alphav-beta3 Integrin-IGF-1-IGF1R Complex Receptor Complex Protein Kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Channel Inhibitor Activity Transferase Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Ubiquitin Binding Transmembrane Transporter Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Activity Insulin-like Growth Factor Receptor Activity Insulin Receptor Binding Structural Molecule Activity Protein Binding Insulin-like Growth Factor Binding ATP Binding Kinase Activity Transferase Activity Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Lysosome Sodium Ion Transport Immune Response DNA Damage Response Lysosomal Transport Nervous System Development Neuromuscular Junction Development Regulation Of Cell Communication Negative Regulation Of Sodium Ion Transport Regulation Of Macroautophagy Protein Ubiquitination Regulation Of Signaling Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV T Cell Activation Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Formation Of Structure Involved In A Symbiotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Biological Quality Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Immune Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transcytosis Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Glucose Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta
Pathways		ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling Respiratory syncytial virus (RSV) attachment and entry
Drugs			Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Nandrolone decanoate Somatrem Insulin beef Insulin degludec Insulin argine Insulin peglispro Insulin tregopil Dalotuzumab Cixutumumab Brigatinib Mecasermin rinfabate BMS-754807 KW-2450 free base
Diseases			Synovial sarcoma Malignant pleural mesothelioma
GWAS		Appendicular lean mass ( 33097823) Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 24292274 28165464) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278)	Adult body size ( 32376654) Alzheimer's disease ( 33074286) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 22354554) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29124443 29403010) Dental caries (decayed and filled deciduous teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometriosis ( 27506219) Estimated glomerular filtration rate ( 31015462 31152163 30604766 29124443) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Height ( 25429064 31562340 33713608 20881960 34270706 28552196) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hyperuricemia ( 29124443) Left ventricle wall thickness ( 33495596) Left ventricular mass ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Offspring birth weight ( 31043758) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) QRS duration ( 30012220) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 29403010 30993211 29124443) Smoking status (ever vs never smokers) ( 30643258) Thyroid volume in Hashimoto’s thyroiditis ( 32019955) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urate levels ( 31578528 31985003 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		282 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AK6 AKT1 AKT3 AMOT AMOTL1 AMPD2 ANK3 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BAIAP2L1 BIRC6 BMPR1A C15orf62 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDIP1 CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CRTC2 CUEDC1 DAZAP2 DCUN1D1 DDN DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EGR1 ENTREP1 EP300 EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 ESS2 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FOXJ3 FYN GABARAP GABARAPL1 GABARAPL2 GBA1 GFUS GJA1 GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HMGCL HNRNPK HNRNPL HNRNPU HNRNPUL1 HRAS IFITM3 IGF1R IL1B IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 KLF5 KRAS LATS1 LDLRAD3 LDLRAD4 LINC01198 LITAF LUC7L2 MAML2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MS4A10 MTMR4 MYCN MYCT1 MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NRAS NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP4P2 PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRR7 PRRG2 PRRG4 PSMD4 PTEN PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RBM14 RET RFT1 RHBDD1 RHBDD2 RNF11 RNF38 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN10A SCN1A SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SQSTM1 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 STRIP2 SULF1 SYK SYNPO2 SYT1 TAF1B TBC1D7 TCEANC TCP11L1 TEAD2 TGFB1I1 THOC1 THRAP3 TMEM139 TMEM252 TMEM51 TNIK TOM1 TOM1L2 TP53BP2 TP63 TP73 TRERF1 TRIM44 TRIM52 TRPV6 TTYH2 TTYH3 TULP4 TUSC2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2L6 UBE2M UBOX5 URI1 UVRAG VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1 ZC3H14	95 interacting genes: AMY2A APP ARHGEF12 BAP1 CAV1 CBL CDK4 CDKN2B CRK CRKL CSK CYP17A1 DOK4 DOK5 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 EEA1 EHD1 ERBB2 ESR1 FFAR2 FGFR4 GIPC1 GNAI1 GNAI2 GRB10 GRB14 GRM1 HOXC6 IGF1 IGF2 IGFBP3 IL13RA2 ILKAP INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KDELR2 KL KLK5 KRT27 LYPD3 MAP3K5 MDM2 MTA3 NAT2 NEDD4 NF2 PIK3R1 PIK3R2 PIK3R3 PPM1A PRKCD PRKD1 PRNP PTPN1 PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RACK1 RASA1 RELA RPL11 SH2B1 SHC1 SIRPA SOCS1 SOCS2 SOCS3 SRC STAT3 STYX THRSP TTYH2 UBC VAV3 VPS45 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		4734	3480
HPRD ID		03786	00932
Ensembl ID		ENSG00000069869	ENSG00000140443
Uniprot IDs		P46934	C9J5X1 P08069
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN 5U8Q 5U8R 6JK8 6VWG 6VWH 6VWI 6VWJ 7PH8 7S0Q 7S8V 7U23 7V3P 7XGD 7XLC 7YRR 8PYI 8PYJ 8PYK 8PYL 8PYM 8PYN 8TAN
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Phosphorylation Intracellular Signal Transduction ATP Binding Nucleotide Binding Phosphorylation WW Domain Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Serine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Protein Autophosphorylation Signal Transduction Cytoplasm Regulation Of Protein Modification Process Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process MAPK Cascade Positive Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Macromolecule Metabolic Process Positive Regulation Of Cell Communication Apoptotic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Positive Regulation Of Signaling Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Programmed Cell Death Cell Surface Receptor Signaling Pathway Cell Death Regulation Of Apoptotic Process Nucleoplasm Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Projection Organization Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Communication	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Insulin-like Growth Factor Receptor Binding Insulin Receptor Binding Negative Regulation Of Signal Transduction Intracellular Signal Transduction Insulin Receptor Signaling Pathway Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Localization Protein Tyrosine Phosphatase Activity Response To Peptide Hormone Positive Regulation Of MAPK Cascade Regulation Of Cellular Localization Positive Regulation Of Protein Localization Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Intracellular Signal Transduction Cytosol Response To Growth Factor Regulation Of Establishment Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Cell Population Proliferation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Transport Response To Hormone Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAPK Cascade Intracellular Signaling Cassette
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?