TERC and DKC1

Number of citations of the paper that reports this interaction (PubMedID 22085966)
60

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		TERC	DKC1
Description		telomerase RNA component	dyskerin pseudouridine synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Telomerase Holoenzyme Complex Cytoplasm Cajal Body Box H/ACA Telomerase RNP Complex	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex
	Molecular Function	Template For Synthesis Of G-rich Strand Of Telomere DNA Activity Telomerase Activity RNA-directed DNA Polymerase Activity Protein Binding Protein-containing Complex Binding DNA Polymerase Binding WD40-repeat Domain Binding	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Telomere Maintenance Via Telomerase Cellular Response To Hypoxia Negative Regulation Of Cellular Senescence	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA Sno(s)RNA 3'-end Processing Pseudouridine Synthesis RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RNA Modification RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Box H/ACA Sno(s)RNA Metabolic Process Ribosome Biogenesis ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body Telomerase Holoenzyme Complex Assembly MRNA Pseudouridine Synthesis
Pathways			Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases		Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)	Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Bladder cancer ( 24163127) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) Glioma ( 28346443) Glioma (high-grade) ( 24908248) Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Multiple myeloma ( 23955597) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418) Telomere length ( 29151059 20139977 23900074 23535734 23001564 21573004) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266)
Interacting Genes		2 interacting genes: DKC1 SMN1	10 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SSR1 TERC
Entrez ID		7012	1736
HPRD ID			02129
Ensembl ID		ENSG00000270141	ENSG00000130826
Uniprot IDs			A0A8Q3SIY6 O60832
PDB IDs			7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Cajal Body Protein Localization To Cajal Body Box H/ACA Sno(s)RNA Metabolic Process Protein-RNA Complex Assembly Box H/ACA Sno(s)RNA 3'-end Processing Box H/ACA SnoRNA Binding Protein Localization To Nucleoplasm SnRNA Pseudouridine Synthesis Box H/ACA SnoRNP Complex Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA ScaRNP Complex Telomerase RNA Stabilization Box H/ACA Telomerase RNP Complex ScaRNA Localization To Cajal Body SnRNA Modification Telomerase Holoenzyme Complex Assembly Telomerase Activity RRNA Pseudouridine Synthesis Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis MRNA Metabolic Process Regulation Of Telomerase RNA Localization To Cajal Body Pseudouridine Synthase Activity SMN Complex Gemini Of Cajal Bodies Pseudouridine Synthesis Sno(s)RNA Metabolic Process SMN-Sm Protein Complex MRNA Modification DNA-templated Transcription Termination Telomerase RNA Binding Telomere Maintenance Via Telomerase Nucleobase-containing Compound Biosynthetic Process RNA Processing Telomerase Holoenzyme Complex Positive Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening RRNA Modification RNA Localization SnRNA Processing Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Protein-containing Complex Assembly Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RNA Metabolic Process
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