ABI2 and WIPF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ABI2	WIPF1
Gene Name		abl-interactor 2	WAS/WASL interacting protein family, member 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium Filopodium SCAR Complex	Ruffle Cytosol Actin Filament Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Rac GTPase Binding Proline-rich Region Binding	Actin Binding Protein Binding Profilin Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization Actin Polymerization Or Depolymerization Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Response To Other Organism
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Butyrylcholinesterase levels ( 21862451) Subclinical atherosclerosis traits (other) ( 17903303)
Protein-Protein Interactions		57 interactors: ABL1 ADAM19 AES ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCDC36 CCDC53 CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MRFAP1L1 MRPL44 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SNAP23 STAM2 TFIP11 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WIPF1	22 interactors: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CDC42 CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A SEC24C WAS WASL WBP4 WWP2 ZAP70
Entrez ID		10152	7456
HPRD ID		07338	03835
Ensembl ID		ENSG00000138443	ENSG00000115935
Uniprot IDs		E9PEZ7 Q9NYB9	O43516 Q2YDC4
PDB IDs		2ED0 3P8C	2A41
Enriched GO Terms of Interacting Partners?		Intracellular Transport Organelle Organization Cell Projection Assembly Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Negative Regulation Of Signaling Cellular Localization Cellular Component Assembly Regulation Of Signal Transduction Cell Projection Morphogenesis Cellular Response To Stimulus Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Cell Cycle Arrest Cell Projection Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Actin Cytoskeleton Organization System Development Actin Filament-based Process Anatomical Structure Development Signaling Intraciliary Transport Cell Morphogenesis Membrane Organization Generation Of Neurons Cell Communication Regulation Of Autophagy Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Protein Localization Protein Transport Neurogenesis Lamellipodium Assembly Signal Transduction Lamellipodium Organization Establishment Of Protein Localization Negative Regulation Of Cellular Senescence Microtubule-based Transport	Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Immune Response Phagocytosis Endocytosis Actin Filament Organization Regulation Of Cytoskeleton Organization Innate Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Immune Response Axon Guidance Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Organelle Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Neuron Projection Morphogenesis Neuron Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle-mediated Transport Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Organization Neuron Differentiation Axonogenesis Cell Projection Organization Cell Projection Morphogenesis Axon Development Cell Part Morphogenesis Actin Polymerization Or Depolymerization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Organelle Organization Immune System Process Immune Response
Tagcloud ?		aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Difference) ?		aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Intersection) ?