ABI2 and KRT14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABI2	KRT14
Description		abl interactor 2	keratin 14
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Adherens Junction Lamellipodium Filopodium SCAR Complex Filopodium Tip Cell Projection Dendritic Spine Anchoring Junction Actin-based Cell Projection	Cornified Envelope Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity SH3 Domain Binding Kinase Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding
	Biological Process	Mitophagy Neuron Migration Cytoskeleton Organization Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Zonula Adherens Assembly Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Morphogenesis Of An Epithelium Epidermis Development Response To Radiation Keratinocyte Differentiation Hair Cycle Intermediate Filament Organization Intermediate Filament Bundle Assembly Stem Cell Differentiation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs			Zinc Zinc acetate
Diseases			Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dermatopathia pigmentosa reticularis Naegeli-Franceschetti-Jadassohn syndrome
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Butyrylcholinesterase levels ( 21862451) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		194 interacting genes: ABI3 ABL1 ABLIM3 ACTMAP ADAM19 AIRIM AKAP8L AKAP9 ANKRD55 ANKS1A ARHGAP32 ARMC7 ATOSB ATP23 BAG4 BIN3 BLOC1S5 BLOC1S6 BORCS6 C1orf216 C20orf202 C4orf17 CCDC102B CCDC57 CCDC74B CCHCR1 CDK6 CENPH CENPQ CEP44 CEP57 CIMIP2B CLPP COG3 CRX CUEDC1 DCTN2 DISC1 DLGAP2 DLGAP4 DNAI7 DTNB EFS EGLN3 EGR4 EIF3H ENAH ENKD1 FAM161B FAM90A1 FAM9C FBXL19 FHL5 FKBP1A FOXD4L1 GAS2L2 GCC1 GFAP GGN GPANK1 HGS HHEX HNRNPK HOMER3 HSF2BP IFT20 IHO1 INCA1 INO80B INSYN1 KHDRBS1 KIAA1217 KIFC3 KNSTRN KRT13 KRT14 KRT15 KRT19 KRT20 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT75 LENG1 LGALS9B LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LNX1 LURAP1 LZTS2 MAGEA1 MCM7 MED10 MED11 MED29 MEOX2 MRFAP1 MRFAP1L1 MRPL28 MRPL44 MYO15B MYOG MYOZ3 NCK1 NCK2 NCKIPSD NFASC NME4 NUP62 OGT OIP5 OOEP PAK2 PCM1 PDLIM7 PFDN5 PHETA1 PHF1 PIN1 PLEKHN1 POMC PPIF PPP3CA PRAM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA1 PWWP2B RABEP1 RABGEF1 RASD1 RNPS1 RPP25 RSPH14 RUSC1 SDCBP SH3BP1 SH3KBP1 SHANK3 SLA SMARCB1 SMARCD1 SNAP23 SNAP91 SNAPIN SNX18 SNX7 SORBS3 STAM2 STX19 STX4 TFIP11 TLE5 TPM2 TRAF3IP1 TRIM32 TRIM72 TRIML2 TRIP6 UBQLN2 USHBP1 USP2 VARS2 VASP VCL VMA22 VPS28 VPS37C WASF2 WASF3 WASHC1 WASHC3 WASL WIPF1 WWOX ZFP90 ZMYND12 ZNF474 ZNF688	35 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DRC4 DST ENKD1 HGS HSPA5 KIFC3 KRT1 KRT3 KRT4 KRT5 KRT6C KRT72 KRT77 KRT78 KRT79 KRT80 KRT81 KRT85 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1
Entrez ID		10152	3861
HPRD ID		07338	01017
Ensembl ID		ENSG00000138443	ENSG00000186847
Uniprot IDs		A0A0C4DG21 A0A7D9NKC8 B7Z836 E9PEZ7 F8WAL6 Q9NYB9	P02533
PDB IDs		2ED0 3P8C 4N78 7USC 7USD 7USE	3TNU 6JFV
Enriched GO Terms of Interacting Partners?		Protein Binding Supramolecular Fiber Organization Organelle Organization Cytoskeleton Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Actin Filament Organization SH3 Domain Binding Cytoskeletal Anchor Activity Plasma Membrane Bounded Cell Projection Assembly Structural Molecule Activity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Cellular Component Assembly Cell Projection Organization Lamellipodium Assembly Epithelial Cell Differentiation Actin Polymerization Or Depolymerization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Postsynaptic Density Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Regulation Of Cytoskeleton Organization Lamellipodium Organization Intermediate Filament Cytoskeleton Actin Cytoskeleton Glutamatergic Synapse Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Translational Initiation Regulation Of Cellular Component Organization Cytoplasm Microtubule-based Process Positive Regulation Of Cytoskeleton Organization Vesicle Organization Positive Regulation Of Cellular Component Biogenesis Protein Localization To Vacuole Intracellular Protein Localization Morphogenesis Of An Epithelium Actin Binding Microvesicle Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Organelle Positive Regulation Of RNA Biosynthetic Process	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Keratinization Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Anchoring Junction Cytosol Cytoskeleton Extracellular Exosome Desmosome Cell-cell Junction Organization Cell Junction Organization Adherens Junction Polymeric Cytoskeletal Fiber Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cell-cell Junction Assembly Actin-based Cell Projection Intermediate Filament Cytoskeleton Microtubule Binding Microtubule Cytoskeleton Cell Junction Assembly Cornified Envelope Protein Binding SCAR Complex Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Structural Molecule Activity Signaling Adaptor Activity Lamellipodium Microtubule Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Microtubule Plus-end Binding Cell-cell Junction Maintenance Cytoskeletal Anchor Activity Structural Constituent Of Cytoskeleton Regulation Of Cell Projection Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Intermediate Filament Polymerization Interleukin-5 Receptor Complex COP9 Signalosome
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