ABI2 and PRR16

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ABI2	PRR16
Gene Name		abl-interactor 2	proline rich 16
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium Filopodium SCAR Complex
	Molecular Function	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Rac GTPase Binding Proline-rich Region Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization Actin Polymerization Or Depolymerization Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Positive Regulation Of Translation Positive Regulation Of Cell Size
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Butyrylcholinesterase levels ( 21862451) Subclinical atherosclerosis traits (other) ( 17903303)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		57 interactors: ABL1 ADAM19 AES ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCDC36 CCDC53 CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MRFAP1L1 MRPL44 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SNAP23 STAM2 TFIP11 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WIPF1	6 interactors: ABI2 APP NEDD4 NEDD4L PPP1CA PPP1CC
Entrez ID		10152	51334
HPRD ID		07338	14239
Ensembl ID		ENSG00000138443	ENSG00000184838
Uniprot IDs		E9PEZ7 Q9NYB9	Q569H4
PDB IDs		2ED0 3P8C
Enriched GO Terms of Interacting Partners?		Intracellular Transport Organelle Organization Cell Projection Assembly Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Negative Regulation Of Signaling Cellular Localization Cellular Component Assembly Regulation Of Signal Transduction Cell Projection Morphogenesis Cellular Response To Stimulus Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Cell Cycle Arrest Cell Projection Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Actin Cytoskeleton Organization System Development Actin Filament-based Process Anatomical Structure Development Signaling Intraciliary Transport Cell Morphogenesis Membrane Organization Generation Of Neurons Cell Communication Regulation Of Autophagy Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Protein Localization Protein Transport Neurogenesis Lamellipodium Assembly Signal Transduction Lamellipodium Organization Establishment Of Protein Localization Negative Regulation Of Cellular Senescence Microtubule-based Transport	Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Light Stimulus Response To Abiotic Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Radiation Negative Regulation Of Sodium Ion Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Regulation Of Potassium Ion Transmembrane Transporter Activity Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Cellular Protein Metabolic Process Protein Monoubiquitination Negative Regulation Of Signal Transduction Neuromuscular Junction Development Negative Regulation Of Signaling Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transport Glycogen Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Signal Transduction Signal Transduction Circadian Regulation Of Gene Expression Protein Metabolic Process Polysaccharide Metabolic Process Signaling Regulation Of Signaling Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Triglyceride Metabolic Process Negative Regulation Of Ion Transport Regulation Of Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To Growth Factor Stimulus Neutral Lipid Metabolic Process Response To Growth Factor
Tagcloud ?		aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana	affecting atp conditional consistent controlling encoding establish functions homeostasis involvement largen led link little maintain mammalian mitochondrial mrnas overexpressing overexpression preferentially product respiration screen size stimulates subsets transgenic translation
Tagcloud (Difference) ?		aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana	affecting atp conditional consistent controlling encoding establish functions homeostasis involvement largen led link little maintain mammalian mitochondrial mrnas overexpressing overexpression preferentially product respiration screen size stimulates subsets transgenic translation
Tagcloud (Intersection) ?