ABI2 and CCDC53

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ABI2	CCDC53
Gene Name		abl-interactor 2	coiled-coil domain containing 53
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium Filopodium SCAR Complex	Actin Cytoskeleton Intracellular Membrane-bounded Organelle WASH Complex
	Molecular Function	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Rac GTPase Binding Proline-rich Region Binding	Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization Actin Polymerization Or Depolymerization Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Biological_process
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Butyrylcholinesterase levels ( 21862451) Subclinical atherosclerosis traits (other) ( 17903303)
Protein-Protein Interactions		57 interactors: ABL1 ADAM19 AES ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCDC36 CCDC53 CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MRFAP1L1 MRPL44 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SNAP23 STAM2 TFIP11 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WIPF1	28 interactors: ABI2 BLOC1S6 CCHCR1 CEP55 CKAP4 DTNBP1 GDF9 GOLGA2 HAUS1 HSBP1 IFT20 KDM1A KRT6A LAMC1 LUC7L2 MCRS1 MOB1B NDC80 NUP62 OPTN PBXIP1 PCM1 PTN SDCBP SNAP25 SYCE1 TXLNA TXLNB
Entrez ID		10152	51019
HPRD ID		07338	13031
Ensembl ID		ENSG00000138443	ENSG00000120860
Uniprot IDs		E9PEZ7 Q9NYB9	F5GZ97 Q9Y3C0
PDB IDs		2ED0 3P8C
Enriched GO Terms of Interacting Partners?		Intracellular Transport Organelle Organization Cell Projection Assembly Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Negative Regulation Of Signaling Cellular Localization Cellular Component Assembly Regulation Of Signal Transduction Cell Projection Morphogenesis Cellular Response To Stimulus Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Cell Cycle Arrest Cell Projection Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Actin Cytoskeleton Organization System Development Actin Filament-based Process Anatomical Structure Development Signaling Intraciliary Transport Cell Morphogenesis Membrane Organization Generation Of Neurons Cell Communication Regulation Of Autophagy Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Protein Localization Protein Transport Neurogenesis Lamellipodium Assembly Signal Transduction Lamellipodium Organization Establishment Of Protein Localization Negative Regulation Of Cellular Senescence Microtubule-based Transport	Organelle Organization Cell Differentiation Establishment Of Localization In Cell Organelle Localization Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Developmental Process Synaptic Vesicle Docking Cell Cycle Mitotic Cell Cycle Process Cell Development Nervous System Development Cell Cycle Process Protein Localization Post-Golgi Vesicle-mediated Transport Microtubule-based Process Intracellular Transport Generation Of Neurons Cell Projection Organization Anterograde Synaptic Vesicle Transport Synaptic Vesicle Transport Membrane Organization Neurogenesis Melanosome Organization Pigment Granule Organization Microtubule-based Movement Anterograde Axon Cargo Transport Establishment Of Organelle Localization Neuron Development Cellular Process Multicellular Organismal Development Cellular Component Assembly Intraciliary Transport Establishment Of Protein Localization Anatomical Structure Development Movement Of Cell Or Subcellular Component Protein Localization To Golgi Apparatus Cytoskeleton Organization Neuron Differentiation Cell Division Regulation Of Primitive Erythrocyte Differentiation Opsin Transport Establishment Of Vesicle Localization Axon Cargo Transport Vesicle Organization Vesicle Localization Neuron Projection Development Positive Regulation Of Cell Proliferation
Tagcloud ?		aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Difference) ?		aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Intersection) ?