ERBB4 and FES

Number of citations of the paper that reports this interaction (PubMedID 22973453)
55

Data Source:
BioGRID (pull down)

		ERBB4	FES
Description		erb-b2 receptor tyrosine kinase 4	FES proto-oncogene, tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Neuromuscular Junction Presynaptic Membrane Organelle Receptor Complex Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Neuregulin Receptor Activity Protein Homodimerization Activity GABA Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Kinase Activity Transferase Activity Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Synapse Assembly Heart Development Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Positive Regulation Of Biosynthetic Process Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Neuron Differentiation Regulation Of Cell Migration Mammary Gland Development ERBB4 Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Mitochondrial Fragmentation Involved In Apoptotic Process Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Planar Polarity Involved In Nephron Morphogenesis Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Neuron Migration	Microtubule Bundle Formation Chemotaxis Centrosome Cycle Cell Adhesion Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cell Population Proliferation Regulation Of Mast Cell Degranulation Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Monocyte Differentiation Protein Autophosphorylation Myoblast Proliferation Positive Regulation Of Cytoskeleton Organization Cardiac Muscle Cell Proliferation Regulation Of Vesicle-mediated Transport Cellular Response To Vitamin D Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Motility
Pathways			Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs		Afatinib Fostamatinib Brigatinib Zanubrutinib	Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (sex interaction) ( 24824216) Atrial fibrillation ( 30061737 29892015) Bell's palsy ( 33602968) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 28892062) Body mass index (change over time) ( 25133637) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Breast cancer ( 22452962) Coronary artery calcification ( 23870195) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gastroesophageal reflux disease ( 34187846) Glomerular filtration rate ( 29403010) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Personality dimensions ( 23903073) Polycystic ovary syndrome ( 26416764 32289280) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Positive urgency ( 30718321) QT interval (ambient particulate matter interaction) ( 28749367) Response to antidepressants (symptom improvement) ( 33589590) Skin aging (microtopography measurement) ( 28502801) Sperm motility ( 29453196) Systemic lupus erythematosus ( 33272962) Systolic blood pressure ( 30224653) Thyroxine levels ( 30843173) Total intracranial volume ( 31530798) Triiodothyronine levels ( 30843173) Type 1 diabetes nephropathy ( 23028342) Urate levels ( 31578528)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28739976 21909115 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Hypertension ( 21909115 31879980) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Number of sexual partners ( 30643258) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Schizophrenia ( 30285260 25056061 29483656) Systolic blood pressure ( 27841878 30578418 27618452 28135244 26390057 28739976 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		152 interacting genes: ABL1 ABL2 ADAM17 ALDOA ANKS1A ANKS1B BCAR3 BLK BTC CCN2 CD44 CDC25C CFL1 CRK DLG1 DLG2 DLG3 DLG4 DUSP10 DUSP14 DUSP16 DUSP18 DUSP19 DUSP21 DUSP6 EGFR ERBB2 ERBB3 EREG ERG28 FAM241B FES FGR FKBP1A GABARAPL2 GRAP2 GRB10 GRB2 GRB7 HBEGF HCK HDAC6 HSH2D ILKAP INPPL1 IRF2BP2 ITCH ITK LCK LCP2 LRRC7 LYN MAGI3 MATK MTMR2 MTMR6 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 NRG3 NRG4 NTRK2 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PRDX5 PRRG4 PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN21 PTPN6 PTPN7 PTPRH PTPRR PTPRT RASA1 RNF41 RTN4 S100A11 SELENOK SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNTB1 SNTB2 SNX27 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SRC STAP1 STAT5A STAT5B STYX SYK SYNM TAB1 TAB2 TEC TFAP2C TGFA TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TRO TVP23B TXK TXN VAV1 VAV2 VAV3 WWOX YAP1 YES1 ZAP70 ZNF532	40 interacting genes: APP AR BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MDFI MET NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID		2066	2242
HPRD ID		02767	01814
Ensembl ID		ENSG00000178568	ENSG00000182511
Uniprot IDs		Q15303	P07332
PDB IDs		2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U 8U4I 8U4J 8U4K 8U4L	1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF 7T1K 7T1L 8X2T 8XKP
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Regulation Of Signal Transduction Protein Tyrosine Phosphatase Activity Regulation Of Signaling Regulation Of Cell Communication Leukocyte Activation Protein Tyrosine Kinase Activity Cell Activation Positive Regulation Of Immune System Process Lymphocyte Activation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Dephosphorylation Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cell Adhesion Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor Tyrosine Kinase Binding Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response ERBB2 Signaling Pathway Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Signal Transduction ERBB4 Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Signaling Pathway Plasma Membrane Activation Of Immune Response Positive Regulation Of Cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Intracellular Signal Transduction Protein Dephosphorylation Fc Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Complex Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Protein Phosphatase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Phosphatidylinositol 3-kinase Binding Protein-containing Complex ErbB-3 Class Receptor Binding Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Binding ERBB2 Signaling Pathway Regulation Of Signal Transduction Interleukin-4-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Programmed Cell Death Interleukin-9-mediated Signaling Pathway Regulation Of Protein Localization Basal Plasma Membrane Protein Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Telomeric D-loop Disassembly Cytosol Regulation Of Cellular Component Organization Cell Activation T Cell Activation Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Insulin Receptor Signaling Pathway Telomeric Loop Disassembly Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Protein Localization
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