ERBB4 and ANKS1B

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		ERBB4	ANKS1B
Gene Name		erb-b2 receptor tyrosine kinase 4	ankyrin repeat and sterile alpha motif domain containing 1B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex	Cytoplasm Postsynaptic Density Cajal Body Cell Junction Dendritic Spine Postsynaptic Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Ephrin Receptor Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 20966902) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 19721433) Waist circumference ( 20966902) Working memory ( 21107309)
Protein-Protein Interactions		39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1	8 interactors: APP EGFR ERBB2 ERBB4 HTR2A LRP1 LRP2 UBC
Entrez ID		2066	56899
HPRD ID		02767	07426
Ensembl ID		ENSG00000178568	ENSG00000185046
Uniprot IDs		Q15303	B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8
PDB IDs		2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U	2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade	Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Transferase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorylation Regulation Of Catalytic Activity Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Proliferation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Diterpenoid Metabolic Process Regulation Of Phospholipase Activity Response To Light Stimulus Positive Regulation Of Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Response To External Stimulus Cell Surface Receptor Signaling Pathway Central Nervous System Development Regulation Of Phospholipase A2 Activity
Tagcloud ?		180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Intersection) ?