ERBB4 and EREG

Number of citations of the paper that reports this interaction (PMID 9419975)
11

Data Source:
HPRD (in vivo)

		ERBB4	EREG
Gene Name		erb-b2 receptor tyrosine kinase 4	epiregulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus	Activation Of MAPK Activity Angiogenesis Ovarian Cumulus Expansion Oocyte Maturation Positive Regulation Of Cytokine Production Female Meiotic Division Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway MRNA Transcription Anatomical Structure Morphogenesis Organ Morphogenesis Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Ovulation Fc-epsilon Receptor Signaling Pathway Wound Healing Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Phosphorylation Luteinizing Hormone Signaling Pathway Response To Peptide Hormone Keratinocyte Proliferation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Primary Follicle Stage Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)	Attention deficit hyperactivity disorder ( 18821565) Breast size ( 22747683) Metabolite levels ( 22916037)
Protein-Protein Interactions		39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1	2 interactors: EGFR ERBB4
Entrez ID		2066	2069
HPRD ID		02767	03638
Ensembl ID		ENSG00000178568	ENSG00000124882
Uniprot IDs		Q15303	O14944
PDB IDs		2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U	1K36 1K37
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade	Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Telencephalon Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Central Nervous System Morphogenesis Astrocyte Activation Positive Regulation Of Protein Transport Positive Regulation Of STAT Protein Import Into Nucleus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Activation Of Phospholipase A2 Activity Regulation Of Intracellular Transport Forebrain Development Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase A2 Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Gland Development Regulation Of Cellular Ketone Metabolic Process Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Transferase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation
Tagcloud ?		180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa
Tagcloud (Difference) ?		180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 folfiri folfox formalin hbegf her3 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa
Tagcloud (Intersection) ?		erbb4 her4