BMP7 and BMPR2

Number of citations of the paper that reports this interaction (PMID 7791754)
79

Data Source:
HPRD (two hybrid, in vivo)

		BMP7	BMPR2
Gene Name		bone morphogenetic protein 7	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Membrane-bounded Vesicle	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Axon Guidance Embryonic Pattern Specification Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Growth Negative Regulation Of Phosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Cartilage Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Regulation Of Removal Of Superoxide Radicals	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Signaling by BMP
Drugs
Diseases
GWAS		Response to citalopram treatment ( 19846067) White blood cell types ( 21738478)	Urate levels ( 23263486)
Protein-Protein Interactions		21 interactors: ACTN4 ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 ENG GDF7 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP5-9 MTUS2 NCOA3 NOG NOTCH2NL SOSTDC1 TRIM27	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		655	659
HPRD ID		00212	02880
Ensembl ID		ENSG00000101144	ENSG00000204217
Uniprot IDs		A8K571 P18075	Q13873
PDB IDs		1BMP 1LX5 1LXI 1M4U	2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Tissue Development Regulation Of Osteoblast Differentiation Pattern Specification Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Ossification Positive Regulation Of Ossification Embryonic Morphogenesis Organ Morphogenesis Tube Development Epithelium Development Mesoderm Development Skeletal System Development Enzyme Linked Receptor Protein Signaling Pathway Gastrulation Regulation Of Transcription From RNA Polymerase II Promoter Tissue Morphogenesis Tube Morphogenesis Regulation Of Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Differentiation Embryo Development Signal Transduction By Phosphorylation Organ Development Regulation Of Signaling Positive Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Phosphorylation Protein Phosphorylation Signal Transduction Developmental Process Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Signaling Cartilage Development Venous Blood Vessel Development Cell Communication Endothelial Cell Differentiation Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?