BMP7 and KRTAP10-9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BMP7	KRTAP10-9
Description		bone morphogenetic protein 7	keratin associated protein 10-9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding	Protein Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Eye Development Metanephros Development Ureteric Bud Development Mesoderm Formation Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Endocardial Cushion Formation Pericardium Morphogenesis Pattern Specification Process Axon Guidance Salivary Gland Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Dendrite Development Neural Fold Elevation Formation Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Hindbrain Development Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Tube Morphogenesis Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Embryonic Camera-type Eye Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cartilage Development Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Embryonic Skeletal Joint Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Cellular Response To BMP Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Brown Fat Cell Differentiation Cell-cell Adhesion Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Allantois Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Multicellular Organismal Development Regulation Of Removal Of Superoxide Radicals
Pathways		Molecules associated with elastic fibres Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Keratinization
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cerebrospinal P-tau181p levels ( 28247064) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Metopic nonsyndromic craniosynostosis ( 32266521) Microalbuminuria in type 1 diabetes ( 31537649) Monobrow ( 27182965) Nose size ( 27182965) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Response to citalopram treatment ( 19846067) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) White blood cell types ( 21738478)
Interacting Genes		32 interacting genes: ACTN4 ACVR1 ACVR2A ACVR2B BEGAIN BMPR1A BMPR1B BMPR2 CCDC125 CHRDL2 CRIPTO CYSRT1 ENG GDF7 KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-1 KRTAP5-9 KRTAP9-8 MTUS2 NBPF19 NCOA3 NOG NOTCH2NLA SOSTDC1 TRIM27	239 interacting genes: ADAMTSL4 ALDH3B1 ALPI ANKS1A ARFGAP1 ATXN7L1 AVPI1 BCL6B BMP7 BRME1 C10orf62 C11orf87 C22orf39 CATIP CATSPER1 CBX2 CCDC26 CD300LG CDKL3 CHIC2 CHRD CHRNG CKS1B CLK4 CNNM3 CRCT1 CREB5 CST9L CXCL16 CYSRT1 DHRS1 DHX57 DMRT3 DOCK2 EIF4E2 EZH2 FAM124B FAM161A FAM74A4 FAM76B FARS2 FBXW5 GABARAPL1 GABARAPL2 GATA2 GLIDR GLP1R GLRX3 GNE GPATCH2L GSTP1 GUCD1 HBG1 HBZ HCK HES6 HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 IGSF8 INPP5D IQUB ITGB4 ITGB5 KAT5 KIAA0040 KIF9 KLHL38 KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LUZP4 MAB21L3 MAPKBP1 MAZ MED30 MEOX2 MOBP MT1DP MXI1 MYPOP NAXD NBPF19 NECTIN3 NKD1 NOTCH2NLA NPBWR2 NPDC1 NPPB NR1D2 NUFIP2 OTX1 PCSK5 PDE9A PDGFRB PGAP2 PGLS PIGS PIN1 PLSCR1 POU4F2 PRKAA2 PRKAB2 PRPF31 PTGER3 PTPMT1 PVR RAB7A RASD1 RHNO1 RSPO2 SCARB1 SCNM1 SEMA3B SHFL SLC23A1 SLC6A20 SMARCE1 SMCP SPACA9 SPATA3 SPATA31J1 SPATA8 SPG7 SPRY1 SPRY2 STK16 TBC1D16 TBC1D23 TBC1D26 TEDC2 TGOLN2 THAP10 TLE5 TNFRSF6B TNP2 TRIM41 TRIM42 TXNDC5 TYMSOS TYRO3 UTP23 VGLL3 WNT11 WT1 WT1-AS XCL2 YIPF3 YY1 ZBTB24 ZBTB38 ZBTB9 ZFYVE26 ZNF124 ZNF155 ZNF165 ZNF20 ZNF251 ZNF264 ZNF275 ZNF286A ZNF317 ZNF319 ZNF417 ZNF433 ZNF439 ZNF440 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF599 ZNF625 ZNF688 ZNF696 ZNF697 ZNF699 ZNF764 ZNF774 ZNF777 ZNF792 ZNF80 ZNF837 ZNF844 ZNF860 ZSCAN21 ZSCAN26
Entrez ID		655	386676
HPRD ID		00212	11195
Ensembl ID		ENSG00000101144	ENSG00000221837
Uniprot IDs		A8K571 P18075	P60411
PDB IDs		1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway BMP Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Keratin Filament Intermediate Filament BMP Binding Cellular Response To BMP Stimulus Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Binding Positive Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Regionalization Pattern Specification Process Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Activity, Type I Mesoderm Development Regulation Of Ossification Response To Growth Factor Osteoblast Differentiation Outflow Tract Septum Morphogenesis Activin Receptor Complex Cardiac Septum Morphogenesis Mitral Valve Morphogenesis Tissue Development Anterior/posterior Pattern Specification Ventricular Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Endocardial Cushion Formation Receptor Complex Mesoderm Formation Morphogenesis Of An Epithelial Fold Gastrulation With Mouth Forming Second Animal Organ Morphogenesis Formation Of Primary Germ Layer Artery Morphogenesis Atrioventricular Valve Morphogenesis Dorsal/ventral Pattern Formation	Intermediate Filament Keratin Filament Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding DNA Binding Hair Cycle Tissue Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Lung Growth
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