BMP7 and KRTAP10-8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		BMP7	KRTAP10-8
Description		bone morphogenetic protein 7	keratin associated protein 10-8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Eye Development Metanephros Development Ureteric Bud Development Mesoderm Formation Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Endocardial Cushion Formation Pericardium Morphogenesis Pattern Specification Process Axon Guidance Salivary Gland Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Dendrite Development Neural Fold Elevation Formation Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Hindbrain Development Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Tube Morphogenesis Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Embryonic Camera-type Eye Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cartilage Development Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Embryonic Skeletal Joint Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Cellular Response To BMP Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Brown Fat Cell Differentiation Cell-cell Adhesion Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Allantois Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Multicellular Organismal Development Regulation Of Removal Of Superoxide Radicals
Pathways		Molecules associated with elastic fibres Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Keratinization
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cerebrospinal P-tau181p levels ( 28247064) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Metopic nonsyndromic craniosynostosis ( 32266521) Microalbuminuria in type 1 diabetes ( 31537649) Monobrow ( 27182965) Nose size ( 27182965) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Response to citalopram treatment ( 19846067) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) White blood cell types ( 21738478)
Interacting Genes		32 interacting genes: ACTN4 ACVR1 ACVR2A ACVR2B BEGAIN BMPR1A BMPR1B BMPR2 CCDC125 CHRDL2 CRIPTO CYSRT1 ENG GDF7 KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-1 KRTAP5-9 KRTAP9-8 MTUS2 NBPF19 NCOA3 NOG NOTCH2NLA SOSTDC1 TRIM27	400 interacting genes: ACY3 ADAM12 ADAMTS1 ADAMTSL3 ADAMTSL4 AEBP2 AEN AK3 ALDH3B1 ALPI ALPP AMMECR1 ANKS1A ANXA2R-AS1 AP1M1 APOL6 AQP1 AREG ARHGAP33 ARID5A ASPSCR1 ATG9A ATP5F1D AVPI1 AXIN2 BAHD1 BCL6B BEX2 BMP7 BRME1 C10orf62 C11orf87 C17orf50 C19orf25 C22orf39 C2orf68 C3 CAMK1G CARD10 CARHSP1 CATSPER1 CCDC26 CCNJL CHIC2 CHRD CHRNG CLK4 CNNM3 COL8A1 COX17 CRCT1 CREB5 CRH CRY2 CSF1 CST2 CTRC CYP2S1 CYSRT1 DAAM2 DCX DDX43 DDX55 DDX6 DERL2 DHRS1 DHX57 DMRT3 DOCK2 ECE1 EFEMP2 EIF4E2 ENKD1 EPDR1 FADS6 FAH FAM110A FAM161A FAM221B FAM27E3 FAM74A4 FAM76B FAM90A1 FARS2 FBXO34 FBXW5 FEZF1 FOXB1 FRS3 FTHL17 FZD10 GARIN6 GEM GFOD1 GLIDR GLP1R GLRX3 GLYAT GNAI2 GNE GOLGA8EP GPANK1 GPHB5 GPRIN2 GRN GUCD1 HAPLN2 HCK HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HS6ST1 HSD3B7 HSPA12B HSPD1 ICAM1 IGFBP6 IGSF8 IL10 IL16 IL2RG INO80B INS INTS5 IP6K3 ITGB2 ITGB4 ITGB5 JOSD1 JPH3 KCNS2 KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-2 KRTAP15-1 KRTAP17-1 KRTAP19-7 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 KSR2 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LENG1 LINC00656 LMF2 LNX1 LRCH4 LRFN4 LUZP4 LYVE1 MACROH2A1 MAPKBP1 MATN3 MEIS2 MELTF MEOX2 MLLT6 MOBP MTA1 MTNR1A MUL1 MXD3 MXI1 MYPOP NAB2 NAXD NBPF19 NECTIN2 NECTIN3 NEK6 NKD1 NOTCH2NLA NPDC1 NR1D2 NR4A3 NTN4 NUFIP2 OLIG3 OPCML OTX1 P2RX7 P2RY6 PAX5 PCED1A PCSK5 PDE9A PDIA4 PGAP6 PGLS PHLDA1 PIGS PIN1 PKD2 PLA2G10 PLSCR4 POM121L8P POU1F1 POU4F2 PRF1 PRKAB2 PRPF31 PRR13 PRR19 PTGER3 PTK7 PTPMT1 PTPRH PVR QPRT R3HDM2 RAB19 RAB3A RALGDS RANBP3 RASD1 RECK RGL2 RHBDL1 RHNO1 RNF38 RNF8 RPS19BP1 RPS28 RTN4RL1 SCARF1 SCNM1 SEMA3B SH3GLB2 SHFL SLC13A5 SLC22A23 SLC23A1 SLC25A10 SLC25A31 SLC25A42 SLC6A20 SLIT1 SMARCE1 SMCP SMG9 SMOC1 SPACA9 SPAG8 SPATA24 SPATA3 SPRY1 SPRY2 SSC4D STK16 SUSD2 SUSD6 SUV39H1 TACSTD2 TAPBPL TBC1D16 TBC1D23 TCAF1 TCEA2 TCEANC TFAP2D TGFB1 THAP10 THAP7 TIE1 TLE5 TMEM140 TMEM150A TMIE TNIP3 TNP2 TNPO3 TNS2 TRIM41 TRIM42 TRPV6 TSPAN4 TTC23 TXNDC5 TYMSOS TYRO3 UBL5 UTP23 UXT VASN VENTX VEZF1 VGLL3 VPS11 VWC2 VWC2L WIF1 WNT11 WT1 WT1-AS YIPF3 YY1 ZBTB24 ZBTB25 ZDHHC1 ZFYVE21 ZIC1 ZNF101 ZNF107 ZNF121 ZNF124 ZNF138 ZNF165 ZNF20 ZNF23 ZNF250 ZNF264 ZNF266 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF419 ZNF439 ZNF440 ZNF444 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF559 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF625 ZNF648 ZNF669 ZNF696 ZNF697 ZNF775 ZNF786 ZNF79 ZNF792 ZNF837 ZSCAN12 ZSCAN21
Entrez ID		655	386681
HPRD ID		00212	11194
Ensembl ID		ENSG00000101144	ENSG00000187766
Uniprot IDs		A8K571 P18075	P60410
PDB IDs		1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway BMP Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Keratin Filament Intermediate Filament BMP Binding Cellular Response To BMP Stimulus Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Binding Positive Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Regionalization Pattern Specification Process Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Activity, Type I Mesoderm Development Regulation Of Ossification Response To Growth Factor Osteoblast Differentiation Outflow Tract Septum Morphogenesis Activin Receptor Complex Cardiac Septum Morphogenesis Mitral Valve Morphogenesis Tissue Development Anterior/posterior Pattern Specification Ventricular Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Endocardial Cushion Formation Receptor Complex Mesoderm Formation Morphogenesis Of An Epithelial Fold Gastrulation With Mouth Forming Second Animal Organ Morphogenesis Formation Of Primary Germ Layer Artery Morphogenesis Atrioventricular Valve Morphogenesis Dorsal/ventral Pattern Formation	Intermediate Filament Protein Binding Keratin Filament Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Hair Cycle Tissue Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Axis Elongation Sequence-specific Double-stranded DNA Binding
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